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Global Head of Precision Oncology

Company: Sanofi-Aventis Belgium S.A.
Location: Cambridge
Posted on: March 17, 2023

Job Description:

Job DescriptionWe are seeking for a highly motivated individual and a proven leader to head our Precision Oncology Team. This group uses both back translational insights and forward translational experiments to advance our Research pipeline and Early Development portfolio. The Head collaborates with Oncology Research scientists to launch new drug discovery programs to target specific patient populations inspired from back-translational insights. The Head also works in a matrix and collaborates with groups outside Oncology Research (e.g., Precision Medicine, Early Clinical Development, Translational Medicine and other functional units) to develop and implement translation medicine plans as well as biomarker assays to guide proof of mechanism and proof of clinical benefit Phase 1 and 2 studies. A successful candidate must be familiar with Data Science and omics technologies, including single-cell, spatial profiling, and high dimensional flow, as well as their utility and application to drive Research and Clinical decision making.Responsibilities

  • Lead a team of over 40+ scientists to formulate and develop translational strategies to support target validation, drug discovery projects and investigational therapeutics in our pipeline
  • Formulate translational medicine strategies for pre-clinical projects, including measuring pharmacodynamic biomarkers to inform decisions for dose selection and schedules
  • Formulate responder hypotheses; lead discovery of biomarkers and data-driven strategies for patient stratification
  • Lead internal efforts and external collaborations with partner companies and academic institutions to further characterize the therapeutic activity of our novel compounds and refine understanding of their mechanism of action to enable indication expansion and novel combination approaches
  • Oversee the management, marshalling, analysis of the genetic, genomic, Real-World Evidence, imaging data required to advance the portfolio
  • Participate in business development meetings and contribute to due diligence efforts
  • Support cross-functional drug development teams
  • Establish group goals, associated budgets and set timelines for deliverables.
  • Present internally and externally to demonstrate the impact and champion the missionRequired Qualifications
    • Ph.D. in cancer biology, computational, biophysics, bioinformatics, or a related field with in-depth knowledge of oncology disease biology and translational science as well as solid understanding of immunology
    • Deep Immuno-Oncology experience as well as knowledge of emerging and current standards of care to define rational combinations
    • A minimum of 12 years of relevant industry experience
    • Demonstrated experience a team leader
    • Proven track record in planning and executing preclinical/early clinical-stage translational projects
    • Ability to drive, manage, execute, and deliver results for complex multi-functional projects
    • Highly developed collaborative working skills
    • Technical expertise for deep analyses of pre-clinical and clinical samples, such as with genomic profiling, bulk and single cell RNA sequencing, multi-parameter flow panels
    • Ability to act as an external Sanofi representative and to influence external organizations.
    • Proven ability to motivate and develop others
    • Strong knowledge of the key business drivers and considerations in the biotech, pharmaceutical, and /or life science industries
    • Strong communication skills written and verbal including presentation skillsAt Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce - and workplace - which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities. According to the CDC, an individual is considered to be "fully vaccinated" fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.#GD-SA#LI-SAAt Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Keywords: Sanofi-Aventis Belgium S.A., Cambridge , Global Head of Precision Oncology, Healthcare , Cambridge, Massachusetts

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