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Sr. Scientist, Gene Therapy

Company: Vedere Bio II
Location: Cambridge
Posted on: May 16, 2022

Job Description:

In your role as a member of the Research Team, you will contribute to the advancement of our platform and discovery programs. Using your expertise in vector biology and molecular biology, you will work with a team of junior scientists and lead from the bench to expand our AAV platform and pipeline projects.
This is an opportunity to be one of the first twenty employees in a rapidly growing, ocular gene therapy startup looking to restore vision to patients who have lost sight due to inherited retinal diseases or other causes. We are a tight-knit, integrated team that places a high importance on doing the best work with intellectual bravery. If you are a self-starter, mature in your understanding of best-in-class laboratory work, and confident in your ability to identify the most important work to be done right now, we would love to speak with you! THE POSITION: Sr. Scientist, Gene Therapy RESPONSIBILITIES:

  • Leads and works with a team of talented scientists to coordinate viral vector production and vector engineering efforts for our gene therapy platform, providing scientific and technical direction
  • Works with junior scientists to evaluate and implement innovative approaches to optimize viral vectors capsids, transgenes, and promoters to support our gene therapy pipeline programs
  • Oversees and contributes to capsid engineering efforts, including DNA library generation, to identify next-generation capsids with tailored properties and tropism
  • Assists in experimental design and troubleshooting
  • Develops and manages relationship with external collaborators and Contract Research Organizations
  • Presents data at external scientific presentations, conferences, and internal meetings
  • Oversees the update and maintenance of accurate, comprehensive laboratory notebooks (eLN)
    QUALIFICATIONS:
    • Ph.D. in Cell Biology, Molecular Biology, Gene Therapy or related field with 5+ years post graduate experience in the biotech/pharmaceutical industry is preferred
    • Hands-on experience with AAV production and purification, transgene construct design, molecular cloning, and testing vector transduction in vitro is highly desired
    • Demonstrated expertise in AAV vector biology, cell and molecular biology, virology and gene therapy
    • Strong critical, scientific, and strategic thinking skills allowing individual to work independently with minimal supervision is required
    • Prior experience with AAV capsids design is highly desired
    • Experience with NGS would be preferred
    • A strong self-starter, independent thinker, with a strong attention to detail
    • Experience managing and mentoring direct reports including PhD level scientists
    • Ability to work collaboratively across a dynamic and collaborative scientific environment
    • Excellent communication skills, both written and verbal, and strong interpersonal skills All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability. No Employment Agencies please, the Company is not responsible for any fees related to candidates that are unsolicited.

Keywords: Vedere Bio II, Cambridge , Sr. Scientist, Gene Therapy, Healthcare , Cambridge, Massachusetts

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