Scientist, Translational Immunology
Company: Jounce Therapeutics, Inc.
Location: Cambridge
Posted on: May 14, 2022
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Job Description:
Role Description
Jounce Therapeutics is seeking an experienced Immunologist to join
the Translational Immunology team and contribute to the development
of novel cancer immunotherapies. The successful candidate will be
executing hands-on immunoassays to develop key mechanism of action
studies across Jounce's pipeline They will also be responsible for
managing multiple aspects of biomarker assays in on-going clinical
trials, including quality control of Flow Cytometry data. As part
of a multi-disciplinary team, they will be expected to proactively
interact with project teams, external collaborators and drive
lab-based research to bring best-in-class biomarker and combination
strategies foe Jounce pipeline programs.
Responsibilities
Execute and develop in lab immunoassays that contribute to
biomarker and drug combination strategies for pipeline
programs;
Gain subject matter expertise for on-going clinical biomarker
assays for JTX-8064 development in the INNATE trial and beyond,
with responsibilities to QC biomarker data from clinical trials as
needed;
Manage and guide the development and execution of future biomarker
assays, working closely with external vendors; and
Work closely and collaboratively with team members, training and
mentoring more junior researchers as appropriate and contributing
efficiently in a matrixed environment.
Qualifications
Ph.D. in Immunology or related field; or M.S. candidates with a
minimum of 10 years of research experience in industry setting and
strong scientific background;
In depth knowledge and hands-on experience with Flow Cytometry
procedures and demonstrated ability to mentor and train junior
associates;
Hands-on experience with Myeloid and T cell centered in vitro
assays;
Experience with the design, development and analysis of cellular,
protein-based, and/or molecular assays;
Good understanding of clinical drug development strategies;
Familiarity with coordinating third party outsourced assays,
standards, interpretation, and reporting;
Experience in immuno-oncology, biologics, molecular biology and
cell biology preferred;
Demonstrated excellent interpersonal, verbal and written
communication skills; and
Experience driving results in and ability to excel in
cross-functional, collaborative and fast-paced settings.
Company Overview
Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company
dedicated to transforming the treatment of cancer by developing
therapies that enable the immune system to attack tumors and
provide long-lasting benefits to patients through a
biomarker-driven approach. Jounce currently has multiple
development stage programs ongoing while simultaneously advancing
additional early-stage assets from its robust discovery engine
based on its Translational Science Platform. Jounce's highest
priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist
shown to reprogram immune-suppressive tumor associated macrophages
to an anti-tumor state in preclinical studies. A Phase 1 clinical
trial, named INNATE, for JTX-8064 as a monotherapy and in
combination with JTX-4014, Jounce's internal PD-1 inhibitor, or
pembrolizumab is currently enrolling patients with advanced solid
tumors. Jounce's most advanced product candidate, vopratelimab, is
a monoclonal antibody that binds to and activates ICOS, and is
currently being studied in the SELECT Phase 2 trial. JTX-4014 is a
PD-1 inhibitor intended for combination use in the INNATE and
SELECT trials and with Jounce's broader pipeline. Additionally,
Jounce exclusively licensed worldwide rights to JTX-1811, a
monoclonal antibody targeting CCR8 and designed to selectively
deplete T regulatory cells in the tumor microenvironment, to Gilead
Sciences, Inc. For more information, please visit
www.jouncetx.com.
Diversity and Inclusion Statement
Jounce strives to create a workplace that reflects the diversity of
cancer patients, and where all feel included and valued because of
their differences. Actively including people who add to our culture
and enhance our values leads to better decisions and outcomes for
those we serve - patients, all patients. Beyond our walls, our
focus is on addressing inequities in opportunities for STEM
education, careers opportunities in Biotech, and access to cancer
care.
Equal Opportunity Employer
Jounce Therapeutics is an equal opportunity employer and does not
discriminate in its employment decisions on the basis of race,
color, national origin, age, physical or mental disability, marital
status, religion, creed, sex, or political beliefs. We offer a
competitive salary and benefits package. All applicants should be
legally entitled to work for any employer in the U.S.
Keywords: Jounce Therapeutics, Inc., Cambridge , Scientist, Translational Immunology, Healthcare , Cambridge, Massachusetts
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