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Scientist, Translational Immunology

Company: Jounce Therapeutics, Inc.
Location: Cambridge
Posted on: May 14, 2022

Job Description:

Role Description
Jounce Therapeutics is seeking an experienced Immunologist to join the Translational Immunology team and contribute to the development of novel cancer immunotherapies. The successful candidate will be executing hands-on immunoassays to develop key mechanism of action studies across Jounce's pipeline They will also be responsible for managing multiple aspects of biomarker assays in on-going clinical trials, including quality control of Flow Cytometry data. As part of a multi-disciplinary team, they will be expected to proactively interact with project teams, external collaborators and drive lab-based research to bring best-in-class biomarker and combination strategies foe Jounce pipeline programs.

Execute and develop in lab immunoassays that contribute to biomarker and drug combination strategies for pipeline programs;
Gain subject matter expertise for on-going clinical biomarker assays for JTX-8064 development in the INNATE trial and beyond, with responsibilities to QC biomarker data from clinical trials as needed;
Manage and guide the development and execution of future biomarker assays, working closely with external vendors; and
Work closely and collaboratively with team members, training and mentoring more junior researchers as appropriate and contributing efficiently in a matrixed environment.

Ph.D. in Immunology or related field; or M.S. candidates with a minimum of 10 years of research experience in industry setting and strong scientific background;
In depth knowledge and hands-on experience with Flow Cytometry procedures and demonstrated ability to mentor and train junior associates;
Hands-on experience with Myeloid and T cell centered in vitro assays;
Experience with the design, development and analysis of cellular, protein-based, and/or molecular assays;
Good understanding of clinical drug development strategies;
Familiarity with coordinating third party outsourced assays, standards, interpretation, and reporting;
Experience in immuno-oncology, biologics, molecular biology and cell biology preferred;
Demonstrated excellent interpersonal, verbal and written communication skills; and
Experience driving results in and ability to excel in cross-functional, collaborative and fast-paced settings.

Company Overview
Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce's highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce's internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce's most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce's broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. For more information, please visit

Diversity and Inclusion Statement
Jounce strives to create a workplace that reflects the diversity of cancer patients, and where all feel included and valued because of their differences. Actively including people who add to our culture and enhance our values leads to better decisions and outcomes for those we serve - patients, all patients. Beyond our walls, our focus is on addressing inequities in opportunities for STEM education, careers opportunities in Biotech, and access to cancer care.

Equal Opportunity Employer
Jounce Therapeutics is an equal opportunity employer and does not discriminate in its employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs. We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

Keywords: Jounce Therapeutics, Inc., Cambridge , Scientist, Translational Immunology, Healthcare , Cambridge, Massachusetts

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