Scientist, Translational Pathology and Biomarker Imaging
Company: Jounce Therapeutics, Inc.
Location: Cambridge
Posted on: May 13, 2022
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Job Description:
Role Description
Jounce Therapeutics is seeking an exceptional Scientist to
contribute to the development of novel therapeutics in the field of
cancer immunotherapy. The successful candidate will be a valued
team member of the Translational Pathology group working on the
development of biomarker assessments, histologic techniques and
image analyses to better understand the tumor micro-environment and
support Jounce`s pipeline. As part of a multi-disciplinary team,
they will be expected to perform wet lab-based science, act as
imaging-based biomarker expert on project teams and provide
oversight of external collaborators. The position provides a great
opportunity to contribute to our translational science-driven drug
development efforts utilizing state-of-the-art imaging techniques
and AI.
Responsibilities
Manage and execute the acquisition and analysis of histologic
samples from internal and external sources;
Provide hands-on support for immunohistochemistry,
immunofluorescence, digital spatial profiling, RNA in situ
hybridization and other tissue-based imaging assays to project
teams and serve as subject matter expert;
Drive exploration and implementation of novel technologies and
approaches for evaluation of predictive and pharmacodynamic
biomarkers in tissues;
Work in close relationship with the Translational Genomics and
Translational Immunology groups on generating biomarker plans and
executing assessments; and
Act as subject matter expert on Program Teams and contribute to
external vendor communication and assay development.
Qualifications
Ph.D. in immunology, pathology or relevant field or MS with 10
years' experience in pathology or immuno-oncology;
Strong wet lab experience and knowledge of molecular biology/cell
biology techniques is required; hands-on expertise with complex
cell- and tissue-based models, e.g. tumor organoids preferred;
Strong background in (tumor) histology and immunostaining
interpretation/scoring required;
Experience and knowledge in specific histology techniques (e.g.
IHC, IF), including the use of automated stainers and imaging
workflow preferred and digital image analysis experience is a plus;
and
Excellent interpersonal, verbal and written communication skills
and demonstrated ability to work in cross-functional, collaborative
and fast-paced settings.
Company Overview
Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company
dedicated to transforming the treatment of cancer by developing
therapies that enable the immune system to attack tumors and
provide long-lasting benefits to patients through a
biomarker-driven approach. Jounce currently has multiple
development stage programs ongoing while simultaneously advancing
additional early-stage assets from its robust discovery engine
based on its Translational Science Platform. Jounce's highest
priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist
shown to reprogram immune-suppressive tumor associated macrophages
to an anti-tumor state in preclinical studies. A Phase 1 clinical
trial, named INNATE, for JTX-8064 as a monotherapy and in
combination with JTX-4014, Jounce's internal PD-1 inhibitor, or
pembrolizumab is currently enrolling patients with advanced solid
tumors. Jounce's most advanced product candidate, vopratelimab, is
a monoclonal antibody that binds to and activates ICOS, and is
currently being studied in the SELECT Phase 2 trial. JTX-4014 is a
PD-1 inhibitor intended for combination use in the INNATE and
SELECT trials and with Jounce's broader pipeline. Additionally,
Jounce exclusively licensed worldwide rights to JTX-1811, a
monoclonal antibody targeting CCR8 and designed to selectively
deplete T regulatory cells in the tumor microenvironment, to Gilead
Sciences, Inc. For more information, please visit
www.jouncetx.com.
Diversity and Inclusion Statement
Jounce strives to create a workplace that reflects the diversity of
cancer patients, and where all feel included and valued because of
their differences. Actively including people who add to our culture
and enhance our values leads to better decisions and outcomes for
those we serve - patients, all patients. Beyond our walls, our
focus is on addressing inequities in opportunities for STEM
education, careers opportunities in Biotech, and access to cancer
care.
Equal Opportunity Employer
Jounce Therapeutics is an equal opportunity employer and does not
discriminate in its employment decisions on the basis of race,
color, national origin, age, physical or mental disability, marital
status, religion, creed, sex, or political beliefs. We offer a
competitive salary and benefits package. All applicants should be
legally entitled to work for any employer in the U.S.
Keywords: Jounce Therapeutics, Inc., Cambridge , Scientist, Translational Pathology and Biomarker Imaging, Healthcare , Cambridge, Massachusetts
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