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Scientist, Translational Pathology and Biomarker Imaging

Company: Jounce Therapeutics, Inc.
Location: Cambridge
Posted on: May 13, 2022

Job Description:

Role Description
Jounce Therapeutics is seeking an exceptional Scientist to contribute to the development of novel therapeutics in the field of cancer immunotherapy. The successful candidate will be a valued team member of the Translational Pathology group working on the development of biomarker assessments, histologic techniques and image analyses to better understand the tumor micro-environment and support Jounce`s pipeline. As part of a multi-disciplinary team, they will be expected to perform wet lab-based science, act as imaging-based biomarker expert on project teams and provide oversight of external collaborators. The position provides a great opportunity to contribute to our translational science-driven drug development efforts utilizing state-of-the-art imaging techniques and AI.

Manage and execute the acquisition and analysis of histologic samples from internal and external sources;
Provide hands-on support for immunohistochemistry, immunofluorescence, digital spatial profiling, RNA in situ hybridization and other tissue-based imaging assays to project teams and serve as subject matter expert;
Drive exploration and implementation of novel technologies and approaches for evaluation of predictive and pharmacodynamic biomarkers in tissues;
Work in close relationship with the Translational Genomics and Translational Immunology groups on generating biomarker plans and executing assessments; and
Act as subject matter expert on Program Teams and contribute to external vendor communication and assay development.

Ph.D. in immunology, pathology or relevant field or MS with 10 years' experience in pathology or immuno-oncology;
Strong wet lab experience and knowledge of molecular biology/cell biology techniques is required; hands-on expertise with complex cell- and tissue-based models, e.g. tumor organoids preferred;
Strong background in (tumor) histology and immunostaining interpretation/scoring required;
Experience and knowledge in specific histology techniques (e.g. IHC, IF), including the use of automated stainers and imaging workflow preferred and digital image analysis experience is a plus; and
Excellent interpersonal, verbal and written communication skills and demonstrated ability to work in cross-functional, collaborative and fast-paced settings.

Company Overview
Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce's highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce's internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce's most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce's broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. For more information, please visit

Diversity and Inclusion Statement
Jounce strives to create a workplace that reflects the diversity of cancer patients, and where all feel included and valued because of their differences. Actively including people who add to our culture and enhance our values leads to better decisions and outcomes for those we serve - patients, all patients. Beyond our walls, our focus is on addressing inequities in opportunities for STEM education, careers opportunities in Biotech, and access to cancer care.

Equal Opportunity Employer
Jounce Therapeutics is an equal opportunity employer and does not discriminate in its employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs. We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

Keywords: Jounce Therapeutics, Inc., Cambridge , Scientist, Translational Pathology and Biomarker Imaging, Healthcare , Cambridge, Massachusetts

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