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Senior Scientist: Cell Enager Therapies and Next Generation COBRAs

Company: Takeda Pharmaceutical
Location: Cambridge
Posted on: May 12, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.OBJECTIVES/PURPOSE The Cell Engager team of the Oncology DDU is seeking a highly motivated Senior Scientist -with demonstrated skills in protein engineering, designing novel immune engager molecules. The interested candidate must have deep subject-matter experience developing and advancing Immunobiologics for Oncology, expertise in program/project leadership, target validation, ideation and interrogation of immune cell functon and screening of therapeutic candidates. The role is a hands-on lab-based research scientist with technical expertise in the field of protein engineering and display technologies that may include monoclonals, and alternative antibody formats such as single domain Abs, Fc fusion proteins and other peptide fusions and non-Ig scaffolds. The candidate should have strong expertise in molecular biology and protein biochemistry and rational design. As a key member of the team, the candidate will be responsible for assessing therapeutic concepts and strategy, various immune engager molecules and advancing novel research molecues towards development candidates and IND. The position will require the candidate to work very closely with Global Biologics for the execution of molecular design strategy and will demonstrate effective communication and documentation of results and collaboration with additional key stakeholders in ODDU (IOI, C2H), GB, DSRE, DMPK, Translational teams, CTI. Ideal applicant will be team-oriented, possess excellent communication and organizational skills.ACCOUNTABILITIES

  • Provides technical and scientific expertise in efforts to understanding drug -dependent innate and/or adaptive immune responses against cancer
  • Scientific driver for research strategy that includes ideation and lead design strategy and implementation of new immune engager concepts (may not be limited to T cells alone) with an initial focus on COBRA iterations as a T cell engager to impact pipeline
  • Oversees various aspects of COBRA iterations: assay design, optimization, validation and implementation as it relates to T cell activation, co-stimulation and related cancer cell targeting and cytotoxicity
  • In collaboration with -Global Biologics design implementation of new COBRA concepts, using AI and ML algorithms
  • Can play a leading scientific role on project teams as PTL or functional lead in collaboration with key stakeholders as part of a cross functional working team with rigor of thought.
  • Characterizes therapeutic candidates in vitro as part of the lead selection process, including tumor target antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity and cytokine release assays.
  • Provides scientific contributions which have significant impact on portfolio progress or development of technical capabilities, based on benchmarking industry best practices.
  • Participates in discussions for prioritization of tumor antigens for immuno-oncology bispecific therapeutics aligned with new engager designs
  • Leads from the bench by providing direct supervision and mentoring to junior level scientist and Research associates.
  • Will contribute to strategic discussions and goal setting with team
  • Executes experiments with minimum supervision and delivers comprehensive high quality data sets to enable decision making
  • Keep up with published literature centered around cancer targets and IO therapies relevant to Takeda's CE strategy
  • Identifies, plans and executes well defined scientific projects and communicates program strategy and timelines to management.
  • Utilizes relevant information, technology and resources, contributing to complex team problem resolution and objectives
  • Interprets results of complex experiments
  • Prepares and presents comprehensive technical or project reports and formal presentations / posters - to full range of internal/external audiences and stakeholders.
  • Maintain laboratory notebooks and follow laboratory practices in compliance with Takeda guidelinesDIMENSIONS AND ASPECTS Technical/Functional (Line) Expertise
    • Demonstrates theoretical knowledge of cell engager platforms
    • Keeps current with emerging trends in immune cell engagers for application in cancer therapy
    • Able to clarify requests and provide suggestions and put data into context especially in context of assay design and quality of data
    • Demonstrates in-depth technical knowledge within various assay development platformsLeadership
      • Indepently investigates new immunological techniques, that can be applied to team projects
      • Serves as the in vitro immunobiology lead on projects providing key scientific feedback to advance programs in a matrixed environment.
      • Develops junior staffDecision-making and Autonomy
        • Independently manages own workload
        • Scientifically independent
        • Provides information to - project teams to influence direction, align with departmental goals and/or businessInteraction
          • Conducts scientific presentations to internal audiences
          • Collaborates with others across sites, and acts as scientific resource for in vitro pharmacology
          • Participates in and supervises external interactions and collaborations with companies and academic research groups and potential collaboratorsInnovation
            • Expected to participate in new target identification / validation process as well as novel approaches for immune cell engagers
            • Strives towards expanding scientific knowledge in immunology
            • Receives high level instructions on work; determines methods on new assignments; demonstrated greater independence; may manage internsComplexity
              • TBD/Not applicableEDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: -
                • PhD with 3+ experience, MS with 9+ - BS with 11+ years experience (industry experience preferred), Structural Biology, Biochemistry Immuno-oncology, bio-engineering.
                • Current knowledge of oncology research, drug discovery and development with an emphasis on immune cell activation, checkpoint blockade, exhaustion pathways as well as markers for anti-tumor efficacy
                • Strong leadership of cross-functional program teams for functional antibody, immunooncology, and CD3 bispecific programs
                • Strong understanding of Molecular Design as it pertains to bispecific immune engager molecules
                • Experience with computational platforms highly preferred
                • Experience or the ability to innovate in novel preclinical -in vitro, -in vivo -and -ex vivo -oncology model development and functional screens that enables bridging from tumor biology to host immunity
                • Experience with biologics is a must (Antibodies, ADCs, Cell therapies etc)
                • Proven ability to design multi-specific molecules with a thorough understanding of molecular biology techniques.
                • Familiarity with preclinical models of immuno-oncology
                • Hands -on basic experience with multi-color flow cytometry, molecular biology techniques (PCR, Gibson assembly, cloning etc), ELISA, MSD and other standard cell based and non-cell based biochemical assays -
                • Experience with mammalian cell culture with best practices in tissue culture
                • Experience with cell engineering and gene editing is preferred
                • Experience in the design and construction of mammalian expression vectors and cell transfection and/or viral-mediated cell transduction, preferably of primary immune cells is preferred
                • Knowledge of drug discovery process and pharmacology is essential.
                • Use of scientific databases and application for data management and data analysis
                • Excellent written and verbal communication skills,
                • Excellent team player with a can-do attitude with an ability to thrive in a dynamic "biotech- like" environment and work in cross-functional project teams
                • Innovative and critical thinking
                • Self-motivated, collaborative with excellent time management and organizational skillsWHAT TAKEDA CAN OFFER YOU:
                  • 401(k) with company match and Annual Retirement Contribution Plan
                  • Tuition reimbursement Company match of charitable contributions
                  • Health & Wellness programs including onsite flu shots and health screenings
                  • Generous time off for vacation and the option to purchase additional vacation days
                  • Community Outreach ProgramsAbsent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.Base Salary Range: $ Range Min to $ Range Mid, based on candidate professional experience level. - Employees may also be eligible for Short Term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. - -This posting is made in compliance with Colorado's Equal Pay for Equal Work Act, C.R.S. - 8-5-101 et seq.Empowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.#LI-JT1EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Cambridge , Senior Scientist: Cell Enager Therapies and Next Generation COBRAs, Healthcare , Cambridge, Massachusetts

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