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Senior Associate Scientist, Gene Therapy

Company: Pfizer
Location: Cambridge
Posted on: April 5, 2021

Job Description:

Senior Associate Scientist, Gene Therapy United States - Massachusetts - Cambridge Pfizer's Rare Disease Research Unit (RDRU) is focused on developing therapeutic solutions for patients with rare disorders. We are seeking a laboratory-based Senior Associate Scientist to execute preclinical experiments in support of the RDRU gene therapy portfolio related to neurological and metabolic diseases. This role will have a strong focus on in cellulo screen as well as ex-vivo recombinant adeno-associated viral (AAV) vector bio-distribution and transduction assessments in preclinical studies. This Senior Associate Scientist will make significant technical contributions under moderate supervision by using established methodologies. In addition, the individual will be encouraged to improve efficiencies of existing protocols and develop novel technical approaches. Role Responsibilities --- AAV bio-distribution studies from different preclinical models such as rodents and non-human primates by determining viral genome copies and transgene expression levels. This work will include sample preparation, DNA/RNA quantifications, data generation, and data QC, ensuring high level of quality and reliability of generated results in support of high-priority projects in the RDRU portfolio --- Performs and develops cell-based, biochemical and histological assays. Familiarity with standard molecular biology methods including but not limited to cell culture, plasmid transfections, immunoassays such as ELISAs and western blotting, quantitative real-time and droplet digital PCR, and immunofluorescence --- Works collaboratively with multiple teams to implement data processing and analysis workflows and data storage procedures. --- Effectively balances resources as needed to achieve timely execution of projects across multiple research teams. --- Willingness to learn from other scientists and implement new techniques. --- Fast learner that can quickly adapt to changing project needs. --- Stays on top of the relevant scientific and technical innovations related to adeno-associated virus (AAV) and genomic technologies. Qualifications --- BS in the life sciences with 3+ years of academic or industry research experience --- 3+ years of experience in cell culture and cell based assays. --- Experience performing DNA/RNA/Protein extractions from both cell lines and tissues, as well as gene quantification using reverse transcription, ddPCR/qPCR, western blotting and ELISA. --- Ability to use appropriate software to perform analysis of data. Experience with experimental design and the interpretation of results. ---Experience with handling laboratory rodents is highly preferred. ---Experience with AAV is highly desired. --- Strong communication skills and demonstrated ability to work effectively as part of a team. Other Job Details:

  • Last Date to Apply for Job: April 1, 2021 Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. Research and Development#LI-PFE Pfizer careers are like no other. In our culture of individual ownership, we believe in our ability to improve future healthcare, and potential to transform millions of lives. We're looking for new talent to join our global community, to unearth new innovative therapies that make the world a healthier place.

Keywords: Pfizer, Cambridge , Senior Associate Scientist, Gene Therapy, Healthcare , Cambridge, Massachusetts

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