Global Group Head /Precision Oncology Molecular Profiling
Company: Patelco Credit Union
Location: Cambridge
Posted on: February 24, 2021
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Job Description:
The health and safety of our employees and candidates is very
important to us. Due to the current situation related to
the--Coronavirus (COVID-19), we're leveraging our digital
capabilities to ensure we can continue to recruit top talent. As
your application progresses, you may be asked to use one of our
digital tools to help you through your recruitment journey. If so,
one of our--colleagues will explain how these tools will be used
throughout the recruitment process and will be on hand to answer
any questions you might have. From Research and Development to
Sales and Marketing, Sanofi offers a wide range of possibilities.
Discover our open positions and become a health journey partner. Do
you have what it takes for a successful career with Sanofi?
Precision Oncology is a dedicated Oncology Research group focused
on increasing success rates in early development by applying High
Content Data and Analytics to inform both Research and early
Development decisions. We work as the intregrated analytical arm of
drug discovery teams and embrace a "Bedside to Bench and Back"
approach to understand at the molecular level cancer subtypes,
immune context, and drug response in patients. Molecular data
(cytometric, single cell and spatial data) as well as advanced
statistical and machine learning methods are used to identify
targets, animals models for hypothesis testing, POC indications,
and biomarkers to for advancing drug discovery programs.
Responsible for applying scientific expertise and judgement to
initiate, design, direct and execute experiments and/or studies in
support of research and/or development projects. Analyzes,
interprets and presents results. Demonstrates continuous growth in
depth and breadth of personal scientific knowledge and
understanding of strategic goals of group, team and company. Works
independently, pro-actively, is an impactful contributor and/or
leader of project teams and transverse initiatives, and
significantly advances R&D goals beyond group. Has a growing
reputation in the external scientific community through high impact
publications, productive scientific collaborations and active
participation in conferences, among other activities. Individuals
in this role may have direct reports, may serve as a Lab Head,
Group Head or equivalent role, and may manage and provide career
development for a group. Key Responsibilities: The Molecular
Profiling Leader manages Sequencing and Cytometery teams in
Cambridge as well as France. A successful candidate will have
direct first experience in: Next Generation Sequencing and
Single-cell Seq platforms including REAP-seq. Immuno-phenotyping
with High content Flow-based cytometry. Digital Spatial Profiling
and assays for monitoring Antigen Specific T-cell expansion. The
Leader will advise project teams on the most appropriate strategies
to address scientific questions. Applications will include somatic
mutation detection, RNA-seq, copy number variation assessment,
working with FFPE tissue, circulating tumor DNA, etc. In addition,
you will participate in external collaborations and lead
interactions with sequencing service providers. The Leader will
work in close collaboration with Data Science and BioInformatics
Leader and Data Scientists to analyze sequencing / flow / spatial
data and extract hypotheses from datasets in support of projects
across all stages of drug development. The Leader will have
responsibility laboratory including scheduling of activities,
experimental strategy and design, and hands-on execution of
projects. You will also participate in the transition of novel
findings to colleagues in assay development and clinical biomarker
integration in order to translate new biomarkers into tools that
drive clinical decisions. An expanded role may be possible based on
experience and motivation. Basic Qualifications: At least 10-years
hands-on laboratory experience with special focus on Sequencing
technologies including Illumina HiSeq, MiSeq, and Sanger platforms.
Experience includes nucleic acid extraction, sample/library
preparation, and data generation. Working knowledge of Flow and
Immuno-phenotyping approaches. Knowledge of key oncogenic pathways
and Immuno-Oncology mechanisms. Demonstrated leadership and
management skills with a track record of managerial experience of
research scientists. Experience in molecular biology techniques
including nucleic acid extraction and quantitation, enzymatic
manipulation of DNA/RNA and PCR. Experience applying sequencing
technologies to pre-clinical oncology model systems and oncology
clinical samples. Working knowledge of data analysis methods and
statistics, and ability to communicate effectively with
bioinformatics and IT colleagues. Experience developing new
experimental applications and methods is a plus. Self-motivated,
independent, and innovative. Excellent written and oral
communications skills. Required Education/Experience: PhD or
equivalent in biology, molecular biology, genomics or related field
with emphasis on cancer is required along with 10-years hands-on
laboratory experience in a drug discovery setting. Significant
hands-on experience generating NGS data is required. Sanofi Inc.
and its U.S. affiliates are Equal Opportunity and Affirmative
Action employers committed to a culturally diverse workforce. All
qualified applicants will receive consideration for employment
without regard to race; color; creed; religion; national origin;
age; ancestry; nationality; marital, domestic partnership or civil
union status; sex, gender, gender identity or expression;
affectional or sexual orientation; disability; veteran or military
status or liability for military status; domestic violence victim
status; atypical cellular or blood trait; genetic information
(including the refusal to submit to genetic testing) or any other
characteristic protected by law. #GD-SA #LI-SA At Sanofi diversity
and inclusion is foundational to how we operate and embedded in our
Core Values. We recognize to truly tap into the richness diversity
brings we must lead with inclusion and have a workplace where those
differences can thrive and be leveraged to empower the lives of our
colleagues, patients and customers. We respect and celebrate the
diversity of our people, their backgrounds and experiences and
provide equal opportunity for all. Join our Talent Network and get
Sanofi communications delivered to your inbox. By submitting your
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and consent to receive email communication from Sanofi.
Keywords: Patelco Credit Union, Cambridge , Global Group Head /Precision Oncology Molecular Profiling, Healthcare , Cambridge, Massachusetts
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