PhD Lab Head, Oncology Translational Research
Company: Novartis Farmac--utica
Posted on: February 20, 2021
PhD Lab Head, Oncology Translational Research Job Description 1
purpose...to reimagine medicine!
The successful candidate is expected to lead biomarker assay
development, and collaborate with CROs to validate clinical assays,
monitor assay performance, and interpret results in the context of
the clinical trial. The candidate will be expected to work with
global multidisciplinary project teams to develop biomarker
clinical strategies that advance Novartis oncology drug candidates.
This individual will participate as a key member of pre-clinical
project teams to generate molecular epidemiology data to inform the
clinical strategy. The investigator role will build patient
stratification hypotheses around public and internally generated
data, develop and implement research plans utilizing all the
cutting-edge translational tools available, communicate the results
with the clinical, biomarker, and research teams, and together
formulate a clinical path forward.
Your Responsibilities will include:
--- Lead assay development for biomarkers across multiple platforms
for readouts of mutations, transcripts, proteins and cell
populations. Responsible for assay transfer to external CROs that
might be used for exploratory clinical endpoints and patient
--- Collaborate with pre-clinical research teams with goal of
developing fit-for-purpose biomarker assays for use in
first-in-human oncology clinical trials
--- Perform exploratory research on commercial and consented
primary human samples.
--- Lead effort for use of peripheral blood and other surrogate
matrices for pharmacodynamic readouts
--- Technical assessment, approval and monitoring of externally run
biomarker assays, assessment and development of novel analytical
platforms to address biomarker needs across both small molecule and
immuno-oncology clinical programs
--- Follow scientific literature and demonstrate initiative toward
new approaches and innovative technical solutions. Provide
strategic scientific input to project teams, lead and manage
scientific associates to design and conduct experiments, to
interpret and challenge experimental results in support of clinical
biomarker assay development across multiple platforms.
--- Represent the Oncology Translational Research group on early
pipeline and clinical stage programs, including providing input on
clinical biomarker strategy, reviewing in-stream clinical biomarker
data and presenting findings and updates to leadership teams.
Present results internally/externally. Write final reports and
EEO Statement The Novartis Group of Companies are Equal Opportunity
Employers and take pride in maintaining a diverse environment. We
do not discriminate in recruitment, hiring, training, promotion or
other employment practices for reasons of race, color, religion,
gender, national origin, age, sexual orientation, gender identity
or expression, marital or veteran status, disability, or any other
legally protected status. We are committed to building diverse
teams, representative of the patients and communities we serve, and
we strive to create an inclusive workplace that cultivates bold
innovation through collaboration and empowers our people to unleash
their full potential. What You Will Bring to the Role:
--- PhD Required in molecular biology, immunology, or relevant
scientific field with 3 years post-doc experience in cancer
--- Strong bench background in molecular and cellular biology
techniques, significant experience with and knowledge of lab
platforms regarding their usability and limitations.
--- Familiarity with cell-based readouts
--- Advanced computer proficiency (Excel, Word, PowerPoint,
Spotfire) and ability to analyze large datasets.
--- Experience in slide-based assays including IHC, fIHC and ISH is
--- Excellent written and oral skills. An orientation towards
strong teamwork, working both collegially and collaboratively is
essential, as is the demonstrated ability to independently drive
and champion projects in a matrix environment.
WHY CONSIDER NOVARTIS?
799 million. That's how many lives our products touched in 2019.
And while we're proud of that fact, in this world of digital and
technological transformation, we must also ask ourselves this: how
can we continue to improve and extend even more people's lives?
We believe the answers are found when curious, courageous and
collaborative people like you are brought together in an inspiring
environment. Where you're given opportunities to explore the power
of digital and data. Where you're empowered to risk failure by
taking smart risks, and where you're surrounded by people who share
your determination to tackle the world's toughest medical
Imagine what you could do at Novartis!
Commitment to Diversity & Inclusion:
Novartis embraces diversity, equal opportunity and inclusion. We
are committed to building diverse teams, representative of the
patients and communities we serve, and we strive to create an
inclusive workplace that cultivates bold innovation through
collaboration, and empowers our people to unleash their full
Join our Novartis Network: If this role is not suitable to your
experience or career goals but you wish to stay connected to learn
more about Novartis and our career opportunities, join the Novartis
Network here: https://talentnetwork.novartis.com/network
Keywords: Novartis Farmac--utica, Cambridge , PhD Lab Head, Oncology Translational Research, Healthcare , Cambridge, Massachusetts
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