Principal Scientist, Translational Research Pathology
Company: Bristol-Myers Squibb
Posted on: February 20, 2021
Principal Scientist, Translational Research Pathology Cambridge
- MA - US At Bristol Myers Squibb, we are inspired by a single
vision - transforming patients' lives through science.--In
oncology, hematology, immunology and cardiovascular disease - and
one of the most diverse and promising pipelines in the industry -
each of our passionate colleagues contribute to innovations that
drive meaningful change. We bring a human touch to every treatment
we pioneer. Join us and make a difference. Principal Scientist,
Translational Research Pathology The new Bristol-Myers Squibb
research site in Cambridge's Kendall Square will help us continue
to deliver on our mission, positioning the company and our
scientists in the heart of a vibrant ecosystem of world-class
science, innovation, and business opportunities. The Mechanisms of
Cancer Resistance (MoCR) Thematic Research Center (TRC) at BMS is
one of the fundamental research and early development engines
delivering oncology therapeutics to patients. The scientists at
this state-of-the-art research and development site in Cambridge
focus on novel tumor intrinsic targets and pathways for tumors that
are refractory to current oncology therapies and implement our
discovery platforms across all of our therapeutic areas of focus.
We are seeking an experienced translational pathology scientist to
support early and late stage drug discovery and clinical
development. The qualified candidate is a highly motivated,
interactive, and creative translational scientist who can work
across a highly matrixed organization to advance programs from lead
initiating/optimization through IND enabling activities and
ultimately to Clinical Proof of Concept. The successful candidate
will provide pathology and assay development support for pathology
biomarker plans, with an ultimate focus on novel targets and
pathways for tumors that are refractory to current therapies.
- Perform histopathologic evaluation of human and mouse tissues
to address specific scientific questions in discovery and
development work in oncology
- Apply relevant pathology techniques, including
immunohistochemistry, flow cytometry, FISH, and molecular
diagnostics in partnership with research and clinical leaders to
discover and characterize drug mechanisms of action and novel
- Manage relationships with key opinion leaders and contract
research organizations (CROs) as part of the Translational Research
- Develop, execute, and interpret biomarker and mechanism of
action studies relevant to early phase clinical trials, with
specific emphases on the development and application of innovative
- Pursue longitudinal reverse translational research activities
to advance the thematic focus on mechanisms of resistance. This
work could involve development and utilization of tissue-based
technologies to support areas of high scientific or translational
interest to discovery or early development efforts.
- Forge strong links across wider translational, discovery and
- Participate in multidisciplinary projects and teams and
integrate cross-functional information.
- Supervision and/or training of junior associates.
- BS/MA or in oncology, pathology or related field
- A minimum of 15 years of relevant biopharma experience using
histopathological techniques to help inform pre-clinical and early
clinical asset development.
- Prior role in multidisciplinary projects and teams with ability
to integrate cross-functional information.
- Strong skill set in developing and implementing multiplexed
immunohistochemistry methodologies from antibody selection,
staining optimization, pre-analytical variable assessment to
downstream digital and imaging strategies, with data dissemination
and evaluation capabilities.
- Image analysis experience is desired.
- Demonstrated ability to handle several projects at any given
time and to work successfully and collaboratively on teams
- Excellent verbal and written communication skills
- Comfortable working in a fast-paced environment where speed is
paramount Around the world, we are passionate about making an
impact on the lives of patients with serious diseases. Empowered to
apply our individual talents and diverse perspectives in an
inclusive culture, our shared values of passion, innovation,
urgency, accountability, inclusion and integrity bring out the
highest potential of each of our colleagues. Bristol Myers Squibb
recognizes the importance of balance and flexibility in our work
environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal lives. W
e're creatinginnovative medicines for patients fighting serious
diseases. We're also nurturing our own diverse team with inspiring
work and challenging career options. No matter the role, each one
of us makes a contribution. And that makes all the difference.
Keywords: Bristol-Myers Squibb, Cambridge , Principal Scientist, Translational Research Pathology, Healthcare , Cambridge, Massachusetts
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