Principal Scientist, Translational Research Pathology

Company: Bristol-Myers Squibb
Location: Cambridge
Posted on: February 20, 2021

Job Description:

Principal Scientist, Translational Research Pathology Cambridge - MA - US At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.--In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. Principal Scientist, Translational Research Pathology The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are seeking an experienced translational pathology scientist to support early and late stage drug discovery and clinical development. The qualified candidate is a highly motivated, interactive, and creative translational scientist who can work across a highly matrixed organization to advance programs from lead initiating/optimization through IND enabling activities and ultimately to Clinical Proof of Concept. The successful candidate will provide pathology and assay development support for pathology biomarker plans, with an ultimate focus on novel targets and pathways for tumors that are refractory to current therapies.

• Perform histopathologic evaluation of human and mouse tissues to address specific scientific questions in discovery and development work in oncology
• Apply relevant pathology techniques, including immunohistochemistry, flow cytometry, FISH, and molecular diagnostics in partnership with research and clinical leaders to discover and characterize drug mechanisms of action and novel biomarkers.
• Manage relationships with key opinion leaders and contract research organizations (CROs) as part of the Translational Research team
• Develop, execute, and interpret biomarker and mechanism of action studies relevant to early phase clinical trials, with specific emphases on the development and application of innovative pathology technologies.
• Pursue longitudinal reverse translational research activities to advance the thematic focus on mechanisms of resistance. This work could involve development and utilization of tissue-based technologies to support areas of high scientific or translational interest to discovery or early development efforts.
• Forge strong links across wider translational, discovery and clinical teams.--
• Participate in multidisciplinary projects and teams and integrate cross-functional information.
• Supervision and/or training of junior associates. Qualifications:
  • BS/MA or in oncology, pathology or related field
  • A minimum of 15 years of relevant biopharma experience using histopathological techniques to help inform pre-clinical and early clinical asset development.
  • Prior role in multidisciplinary projects and teams with ability to integrate cross-functional information.
  • Strong skill set in developing and implementing multiplexed immunohistochemistry methodologies from antibody selection, staining optimization, pre-analytical variable assessment to downstream digital and imaging strategies, with data dissemination and evaluation capabilities.
  • Image analysis experience is desired.
  • Demonstrated ability to handle several projects at any given time and to work successfully and collaboratively on teams
  • Excellent verbal and written communication skills
  • Comfortable working in a fast-paced environment where speed is paramount Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. W e're creatinginnovative medicines for patients fighting serious diseases. We're also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference.

Keywords: Bristol-Myers Squibb, Cambridge , Principal Scientist, Translational Research Pathology, Healthcare , Cambridge, Massachusetts