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VP, TTR Franchise Head

Company: Alnylam
Location: Cambridge
Posted on: November 15, 2023

Job Description:

Work_Category - hybrid Description Overview
The Vice President, TTR Franchise Head is a pivotal role that will be responsible for program/asset leadership and all aspects of global commercialization for our transthyretin (TTR) amyloidosis franchise, currently comprised of Onpattro, Amvuttra, and ALN-TTR-sc04 (a next-generation compound currently in development). The multi-billion-dollar TTR market is projected to grow significantly in the next several years with the entry of multiple players. The Vice President, TTR Franchise Head, in close collaboration with the cross-functional leaders of all relevant functions (e.g. Clinical Development, Regulatory, Drug Safety, Manufacturing, Commercial, Medical Affairs), will ensure optimal development and commercial success of all TTR assets, including clinical development planning, pre/launch planning (including global brand strategy, positioning, and messaging), competitive awareness/readiness, and life-cycle planning. Additionally, the Vice President, TTR Franchise Head will work closely with regions and key markets to understand regional/local commercial dynamics in order to drive commercial success of launches and ongoing success of in-market medicines.
The ideal candidate will be a strategic leader versed in driving cross-region, cross-functional commercial success, and ideally with experience in drug development, in-country/region commercialization, and matrix leadership. S/he will be a strong influencer with a competitive mindset who can integrate multiple perspectives effectively and align stakeholders across different functions and levels of the organization.
This will be a highly visible role, interacting extensively with the heads of all key functions at Alnylam, as well as the Executive Leadership Team (ELT / C-suite) and the Board of Directors.
This role will report to the Senior Vice President of Global Commercial.
This position is onsite / hybrid onsiteand will be primarily located at Alnylam headquarters in Cambridge, MA.
Key Responsibilities

  • Lead the TTR Global Franchise program/asset team and global marketing team, and serve as the single point of accountability for all things spanning the development and commercialization of Alnylam's TTR franchise.
  • Collaborate closely with leaders and colleagues from Clinical Development functions, including Clinical Operations, Regulatory, Statistics, and Drug Safety to optimize and accelerate clinical development plans, prepare for data readouts, and engage with regulatory agencies in study planning and label negotiations.
  • Collaborate closely with leaders and colleagues from TOQ (Technical Operations & Quality) in planning for TTR studies, bringing TTR medicines to market, and manufacturing/distributing adequate and reliable supply for in-market TTR medicines.
  • Lead Global Marketing for the TTR franchise, and collaborate closely with key Global Commercial functions including Pricing & Market Access, Insights & Analytics, and Launch Excellence, as well as Global Medical Affairs, and regional/country colleagues, to build and optimize launch and commercialization strategies that are highly competitive and deliver lasting impact.
  • Oversee development/refinement of annual objectives for the Global TTR Franchise, annual strategic and tactical plans for TTR marketed (or pre-launch) brands, and the life-cycle management plan for the TTR franchise.
  • Oversee proactive monitoring of competitor activities including competitor studies, data readouts, and investor/analyst engagements, and provide interpretation/implication of these competitor activities for Alnylam's TTR Franchise.
  • Work closely with Corporate Communications to shape and refine external messaging for the TTR Franchise to be used by Alnylam senior leadership in investor conferences, quarterly earnings calls, and analyst meetings.
  • Cultivate relationships with the top experts, Key Opinion Leaders, and patient advocates in the treatment of ATTR amyloidosis to ensure all aspects of planning include a strong external perspective.
  • Lead a team of 4-6 direct reports (which is expected to grow) and cultivate a culture of bold and innovative thinking, purposeful urgency, a passion for excellence, and a commitment to developing talent.


    • Deep understanding of, and experience with, global and regional/country product commercialization in highly competitive markets with medium to large-sized patient populations. Deep US market experience is a must. Experience in drug development and global product registration is a plus.
    • Ability to influence cross-functionally and drive alignment within the team, with peers, and with senior management. Demonstratable level of executive presence.
    • Ability to operate at both the strategic and tactical level, with the ability to seamlessly move between both perspectives.
    • Proactive "hands-on" individual with collaborative orientation, who manages matrix teams effectively, is very self-motivated, and can smoothly establish and sustain strong working relationships within both internal and external organizations and experts.
    • Strong patient/physician/market-centricity that is infused in discussions and decision-making.
    • Initiative and independence to identify short and long-term program needs, creatively formulate plans with team input, efficiently achieve timely decisions/alignment, and organize and deploy resources.
    • Exceptional written and verbal communication skills. Ability to articulate program vision and motivate the team; communicates in an open, direct, and timely manner; ensures broader organization is aligned with and aware of the program strategy, status, and risks.
    • Decisive as well as collaborative. Can flex when needed and pursues data-driven decisions.
    • BA/BS degree required; advanced scientific or business degree strongly preferred.
    • 10+ years of varied biopharmaceutical or related experience, including global/international matrix team responsibilities.

      About Alnylam
      Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.
      Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2022, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2023 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.
      At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.
      Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law. Alnylam is an E-Verify employer.

Keywords: Alnylam, Cambridge , VP, TTR Franchise Head, Executive , Cambridge, Massachusetts

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