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Senior Director, Medicinal Chemistry Chemistry

Company: FogPharma
Location: Cambridge
Posted on: May 25, 2023

Job Description:

Why join us?
FogPharma - is pioneering the discovery, development, and commercialization of HeliconTM peptides, an exciting new drug modality that uniquely combines the cell-permeability of traditional small molecule drugs with the specificity, broad target accessibility and discovery speed of monoclonal antibody drugs. Our patented Heliconpeptide technology allows us to modulate the activity of well-known intracellular disease drivers that have thus far evaded small molecule and biologic therapies.
FogPharma's lead program targets ---Catenin, a cancer driver in the WNT pathway. Inhibition of ---Catenin has the potential to benefit more than one-fifth of all cancer patients, and is just one of many opportunities for Fog's lead-discovery platform to change future medicines, therapies and lives. We recently selected a lead development candidate and plan to initiate clinical development early this year.
What's the opportunity?

  • Drive progression of lead Helicons to pharmacological proof-of-concept studies and development candidate nomation.
  • Formulate and implement an integrated chemistry strategy, working in concert with partners in de novo discovery, molecular and cellular biology, and pharmacology to reach hit-to-lead/lead optimization goals.
  • Lead and inspire a highly talented team of medicinal chemists. Serve as a scientific expert in medicinal chemistry with both internal and external partners to generate new research ideas and initiatives. Identify sources of inefficiency and propose solutions. Ensure optimal coordination and efficiency across the full R&D team.
  • Set ambitious goals and timelines for reaching key discovery milestones and rapid delivery of first-in-class Helicon--- peptide drugs to patients.
  • Liaise with CROs and manage external projects to obtain compounds critical to achievement of corporate goals.
  • Participate in company portfolio and stage-gate reviews, lead the preparation and presentation of program advancement.
  • Collaborate with Lead IP Counsel to formulate intellectual property strategies.

    What you'll need to be successful:

    • Ph.D. in Chemistry with 15+ years of work experience, of which at least 10 years should be in drug discovery.
    • Demonstrated expertise and a track record of success in advancing discovery programs from target validation through lead optimization and into clinical development.
    • Innovative thinker with experience as a successful therapeutic program team (co)leader.
    • Expert knowledge of modern methods of peptide and medicinal chemistry with ability to conduct medicinal chemistry successfully and simultaneously on multiple projects/series.
    • Experience in overseeing and directing the day-to-day scientific activities of a medicinal chemistry team.
    • Solid understanding of cellular/molecular biology, biochemistry, mechanisms of drug metabolism, pharmacokinetic and pharmacodynamic sciences
    • Ability to motivate team and find creative solutions to problems. Demonstrated influence, negotiation, and conflict resolution skills.
    • Capacity to execute tasks independently to achieve company goals on an established timeline.
    • Excellent communication, organization, multi-tasking, flexibility, and team skills.
    • Enthusiasm to work in a dynamic research environment.
    • Able to work on-site and attend in-person meetings (Fog employees are required to be fully vaccinated to attend in-person work-related activities. Reasonable Accommodations will be made for individuals with a sincerely held religious belief or disability who are not vaccinated)

      As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
      30 Acorn Park Drive - Cambridge, MA 02140 -

Keywords: FogPharma, Cambridge , Senior Director, Medicinal Chemistry Chemistry, Executive , Cambridge, Massachusetts

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