Senior Director, Medicinal Chemistry Chemistry
Company: FogPharma
Location: Cambridge
Posted on: May 25, 2023
Job Description:
Why join us?
FogPharma - is pioneering the discovery, development, and
commercialization of HeliconTM peptides, an exciting new drug
modality that uniquely combines the cell-permeability of
traditional small molecule drugs with the specificity, broad target
accessibility and discovery speed of monoclonal antibody drugs. Our
patented Heliconpeptide technology allows us to modulate the
activity of well-known intracellular disease drivers that have thus
far evaded small molecule and biologic therapies.
FogPharma's lead program targets ---Catenin, a cancer driver in the
WNT pathway. Inhibition of ---Catenin has the potential to benefit
more than one-fifth of all cancer patients, and is just one of many
opportunities for Fog's lead-discovery platform to change future
medicines, therapies and lives. We recently selected a lead
development candidate and plan to initiate clinical development
early this year.
What's the opportunity?
- Drive progression of lead Helicons to pharmacological
proof-of-concept studies and development candidate
nomation.
- Formulate and implement an integrated chemistry strategy,
working in concert with partners in de novo discovery, molecular
and cellular biology, and pharmacology to reach hit-to-lead/lead
optimization goals.
- Lead and inspire a highly talented team of medicinal chemists.
Serve as a scientific expert in medicinal chemistry with both
internal and external partners to generate new research ideas and
initiatives. Identify sources of inefficiency and propose
solutions. Ensure optimal coordination and efficiency across the
full R&D team.
- Set ambitious goals and timelines for reaching key discovery
milestones and rapid delivery of first-in-class Helicon--- peptide
drugs to patients.
- Liaise with CROs and manage external projects to obtain
compounds critical to achievement of corporate goals.
- Participate in company portfolio and stage-gate reviews, lead
the preparation and presentation of program advancement.
- Collaborate with Lead IP Counsel to formulate intellectual
property strategies.
What you'll need to be successful:
- Ph.D. in Chemistry with 15+ years of work experience, of which
at least 10 years should be in drug discovery.
- Demonstrated expertise and a track record of success in
advancing discovery programs from target validation through lead
optimization and into clinical development.
- Innovative thinker with experience as a successful therapeutic
program team (co)leader.
- Expert knowledge of modern methods of peptide and medicinal
chemistry with ability to conduct medicinal chemistry successfully
and simultaneously on multiple projects/series.
- Experience in overseeing and directing the day-to-day
scientific activities of a medicinal chemistry team.
- Solid understanding of cellular/molecular biology,
biochemistry, mechanisms of drug metabolism, pharmacokinetic and
pharmacodynamic sciences
- Ability to motivate team and find creative solutions to
problems. Demonstrated influence, negotiation, and conflict
resolution skills.
- Capacity to execute tasks independently to achieve company
goals on an established timeline.
- Excellent communication, organization, multi-tasking,
flexibility, and team skills.
- Enthusiasm to work in a dynamic research environment.
- Able to work on-site and attend in-person meetings (Fog
employees are required to be fully vaccinated to attend in-person
work-related activities. Reasonable Accommodations will be made for
individuals with a sincerely held religious belief or disability
who are not vaccinated)
As an equal opportunity employer, Fog values diversity and welcomes
applicants of all backgrounds and experiences. All qualified
applicants will receive consideration for employment without
discrimination on the basis of race, color, religion, sex, sexual
orientation, gender identity, national origin, protected veteran
status, disability, or any other factors prohibited by law.
30 Acorn Park Drive - Cambridge, MA 02140 - www.fogpharma.com
Keywords: FogPharma, Cambridge , Senior Director, Medicinal Chemistry Chemistry, Executive , Cambridge, Massachusetts
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