Associate Director - Molecular Informatics
Company: Bristol Myers Squibb
Location: Cambridge
Posted on: March 18, 2023
Job Description:
At Bristol Myers Squibb, we are inspired by a single vision -
transforming patients' lives through science. -In oncology,
hematology, immunology and cardiovascular disease - and one of the
most diverse and promising pipelines in the industry - each of our
passionate colleagues contribute to innovations that drive
meaningful change. We bring a human touch to every treatment we
pioneer. Join us and make a difference.Job DescriptionWe seek a
collaborative and highly innovative computational research leader
to join our Predictive Sciences team and develop novel approaches
at the interface of structural bioinformatics, chemoinformatics,
and predictive molecular design that originate, elucidate, and
prioritize the next generation of targeted protein degradation
therapies for both hematological and solid tumor indications.
-Working alongside BMS Research & Early Development colleagues in
the Protein Homeostasis Center of Excellence, Small Molecule Drug
Design and other teams in the global Informatics and Predictive
Sciences (IPS) department, the successful applicant will play a key
scientific role in shaping the future of our most advanced protein
degrader compound libraries to pursue therapeutic opportunities in
spaces beyond the reach of conventional small molecule drug
approaches. -This role offers the opportunity to directly impact
the origination and delivery of transformational therapies in key
diseases of unmet medical need by innovating and applying leading
computational research approaches. A strong track record in the
inter-disciplinary application of computational research at the
junction of biology and chemistry to empower complex life sciences
and therapeutic discovery objectives is imperative.
-Responsibilities
- Build and lead an internal team of structural bioinformatics,
chemoproteomics, chemogenomics and systems biology
researchers.
- Drive predictive research across multi-dimensional compound
profiling datasets to elucidate functional activity phenotypes and
their association with molecular structure
- Collaborate closely with Computer Aided Drug Design team to
leverage findings within predictive structure-property relationship
models for chemical optimization and compound library expansion
into novel chemical space.
- Pioneer drug-target interaction modeling via application of
state-of-the-art methods for protein folding and partner with
Protein Homeostasis colleagues to leverage predicted protein
structures for identification and refinement of neosubstrate
recruitment modes.
- Design and implement computational strategies that elucidate
protein degradation biophysics, kinetics and substrate
specificity.
- Collaborate in matrix teams to prioritize protein degradation
MoAs and predict potential therapeutic effects on patient disease
states in key indications.
- Author scientific reports and present methods, results, and
conclusions to publishable standard.
- Contribute to planning and execution of collaborative projects
with leading academic and commercial research groups
worldwide.Background experience & complementary knowledge
- Ph.D. in interdisciplinary fields including computer science,
systems biology, structural bioinformatics, chemoinformatics from a
recognized higher-education establishment.
- 10+ years of research experience in applying predictive
computational approaches to elucidate complex interactions between
human disease biology and therapeutic drug modalities in
university, pharma, or biotech research environments.
- Demonstrated ability to integrate heterogeneous data sources
and apply predictive, multivariate research approaches to
integrated molecular and chemistry datasets.
- Proven expertise in development and implementation of
algorithms to distill, analyze and interpret complex drug MoA
and/or molecular perturbation datasets.
- Experience of computational biology research on a wide variety
of molecular and phenotypic profiling platforms, including
proteomics, mRNA profiling and high content imaging assays.
- Strong working knowledge of molecular properties, chemical
interactions, and drug discovery plus experience with contemporary
cheminformatics methods and related research tools (e.g.,
RDKit).
- Expertise in state-of-the-art machine learning methods, such as
graph convolutional neural networks, generative models, and
reinforcement learning.
- Track record of peer-reviewed publications in top-tier
scientific journals and supervision of computational research.
- Proven problem-solving skills, collaborative nature, and
adaptability across disciplines.
- Excellent verbal and written communication skills. Fluent
verbal and written English language skills prerequisite.Around the
world, we are passionate about making an impact on the lives of
patients with serious diseases. Empowered to apply our individual
talents and diverse perspectives in an inclusive culture, our
shared values of passion, innovation, urgency, accountability,
inclusion and integrity bring out the highest potential of each of
our colleagues.Bristol Myers Squibb recognizes the importance of
balance and flexibility in our work environment. We offer a wide
variety of competitive benefits, services and programs that provide
our employees with the resources to pursue their goals, both at
work and in their personal lives. -Physical presence at the BMS
worksite or physical presence in the field is an essential job
function of this role which the Company deems critical to
collaboration, innovation, productivity, employee well-being and
engagement, and enhances the Company culture.To protect the safety
of our workforce, customers, patients and communities, the policy
of the Company requires all employees and workers in the U.S. and
Puerto Rico to be fully vaccinated against COVID-19, unless they
have received an exception based on an approved request for a
medical or religious reasonable accommodation. - Therefore, all BMS
applicants seeking a role located in the U.S. and Puerto Rico must
confirm that they have already received or are willing to receive
the full COVID-19 vaccination by their start date as a
qualification of the role and condition of employment. - This
requirement is subject to state and local law restrictions and may
not be applicable to employees working in certain jurisdictions
such as Montana. This requirement is also subject to discussions
with collective bargaining representatives in the U.S.Our company
is committed to ensuring that people with disabilities can excel
through a transparent recruitment process, reasonable workplace
adjustments and ongoing support in their roles. Applicants can
request an approval of accommodation prior to accepting a job
offer. If you require reasonable accommodation in completing this
application or if you are applying to a role based in the U.S. or
Puerto Rico and you believe that you are unable to receive a
COVID-19 vaccine due to a medical condition or sincerely held
religious belief, during or any part of the recruitment process,
please direct your inquiries to . Visitto access our complete Equal
Employment Opportunity statement.Any data processed in connection
with role applications will be treated in accordance with
applicable data privacy policies and regulations.
Keywords: Bristol Myers Squibb, Cambridge , Associate Director - Molecular Informatics, Executive , Cambridge, Massachusetts
Didn't find what you're looking for? Search again!
Loading more jobs...