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Senior Director, In vivo Pharmacology

Company: HireMinds
Location: Cambridge
Posted on: November 25, 2022

Job Description:

Director/Senior Director, In vivo Pharmacology
Cambridge-based biotechnology startup on a mission to create therapies for diseases inaccessible to existing approaches. We are leading the next wave of RNA therapeutics with our best-in-class expression and delivery platform. We are seeking an exceptional Director/Senior Director, In vivo Pharmacology to identify novel therapeutic opportunities and advancing our platform for enhanced tissue delivery, efficacy and safety. The successful candidate will build and lead a highly integrated scientific team working seamlessly with research teams to drive projects to completion, bringing new and exciting drugs to IND. A deep understanding of gene therapy and the appropriate application of in vivo models to assess target engagement, disease interruption, and potential liabilities is expected. Emerging problems will be met with evidence-based solutions.
Extensive experience working with rodent and non-rodent animal models internally and with CROs is an essential requirement. In addition to bench assays, the leader will understand and correctly interpret data from in vivo studies including gross findings, clinical pathology, histologic changes, and in situ molecular profiling by immunohistochemistry, in situ hybridization, spatial-seq, etc. The position requires an ability to see beyond the ordinary and identify novel opportunities revealed by disparate data streams.
The ideal candidate holds a PhD in a biomedical discipline, and / or board certification in veterinary or and is recognized leader in both investigative research. The position requires a deep understanding of gene therapy and the appropriate application of in vivo models to assess target engagement, disease interruption, and potential liabilities. The successful candidate will have strong communication skills, team-first collegiality, and an ability to manage multiple parallel activities in a fast-paced environment.

  • PhD in the life sciences and/or DVM/MD.
  • 12+ years' experience as an independent in vivo biomedical researcher.
  • 4+ years managing PhD-level scientists in biopharma.
  • Experience in gene therapy including RNAi, mRNA and/or CRISPR/Cas9.
  • Drug development experience working with small molecules, biologics, and/or cell & gene therapy through lead optimization to candidate selection, with broad knowledge across multiple disciplines including cancer biology and pharmacology.
  • Strong background in disease research with a thorough understanding of signaling pathways and mechanism of action for targeted therapies.
  • Experience analyzing a broad array of molecular, cell biology and in vivo outcomes.
  • Track record of novel target discovery and safety assessment.
  • Demonstrated ability to manage and work with teams of highly skilled scientists and research associates in a fast-paced, entrepreneurial environment.
  • Expertise in animal model development, characterization/study design, and implementation in a scientific/development/contract organization is essential.
  • Knowledge of global regulatory guidelines (GMP/ICH/GLP/OECD) is a plus.

Keywords: HireMinds, Cambridge , Senior Director, In vivo Pharmacology, Executive , Cambridge, Massachusetts

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