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Director, Translational Research

Company: Glympse Bio
Location: Cambridge
Posted on: November 18, 2022

Job Description:

About UsGlympse Bio is pioneering the development of synthetic biomarkers - biochemical sensors developed using breakthroughs in science, engineering, medicine and artificial intelligence - that are engineered to be tunable to a range of diseases and offer earlier measures of response to disease and treatment. Our breakthrough technology measures protein activity from a blood draw to revolutionize disease diagnosis and monitoring. We are building a novel biomarker technology platform from the ground up, laying the foundation for innovative diagnostics which combines nanotechnology with AI to improve the lives of potentially millions of patients worldwide.We are a vibrant and dedicated team working at the forefront of scientific discovery and clinical development. We are agile, resilient, and creative problem solvers. We are committed to bringing the best products to patients and at Glympse you will have the opportunity to work alongside a high functioning, interdisciplinary and collaborative team to develop an entirely new diagnostic modality.Position SummaryWe are seeking a highly motivated, innovative, and collaborative PhD Biologist to lead biomarker discovery and characterization efforts in a range of indications including liver disease, oncology, and immunology. Reporting to the CSO, the Head of Biology will have a key role leading a small team of biologists and partnering with key stakeholders in Chemistry, Data Science, and Clinical Development to discover and develop novel diagnostics using Glympse's innovative protease activity platform. This position will be an important member of the R&D leadership team and participate in building the scientific vision of the company. The successful candidate will have a strong background in human disease biology, molecular assays and biomarker discovery and be able to drive fast-paced assay development and technology innovation in a startup environment.Responsibilities

  • Lead and contribute to biomarker discovery and diagnostic development programs in liver disease, oncology, immunology, or related fields.
  • Provide insights into disease mechanisms to guide experimental design across all programs.
  • Lead and mentor a team of Biology scientists and associates; communicate goals, timelines and objectives clearly to ensure success.
  • Design and execute experiments either internally or through partner to evaluate biomarker target dependency, phenotypic responses, and identify roles in disease pathogenesis.
  • Supervise in vitro, preclinical, and early clinical research to develop, validate and implement biomarkers and pharmacodynamic mechanism assays including ELISA-based assay, flow cytometry, kinetic assays, western blotting, QPCR, and other molecular techniques.
  • Partner with Research, Clinical and Commercial groups to support clinical studies, product launches, and regulatory submissions.
  • Support research collaborations with external partners.
  • Process, interpret, and communicate data to multidisciplinary project teams.
  • Appropriately document experimental procedures and results according to established guidelines.
  • Identify new directions for research and contribute to Glympse Bio's culture of innovation.
  • Lead scientific publications.Qualifications
    • Ph.D. in Molecular Biology, Biochemistry, Biology or related field
    • 5-10 years of experience working in an academic or industry labs with a proven track record in biomarker discovery and preclinical research
    • Prior experience leading a program or multiple programs in parallel in an industry setting
    • Experience supervising associate and scientist level employees
    • Expertise in oncology, liver disease, and/or autoimmune diseases strongly preferred
    • Technical understanding of protein and/or enzyme-based assays
    • Experience in cell based assay development and / or diagnostics preferred
    • Demonstrated ability to troubleshoot technical and scientific issues, both individually and as part of a team
    • Proven ability to communicate and collaborate cross-functionally
    • Experience building teams and creating a strong team culture; ability to lead, motivate, and manage staff
    • Excellent organizational skills and ability to creatively solve ambiguous challengesThe Ideal Candidate--- Brings courage, character, humility, and energy to work every day--- Is motivated to improve the lives of the people they serve--- Is excited about what might be possible, sees problems as challenges to be overcome, and is driven by curiosity and creativity--- Is optimistic and committed to Glympse's missionEEO DisclosureWe are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to age, color, creed, disability, gender identity, national origin, protected veteran status, race, religion, sex, sexual orientation, and any other status protected by applicable local, state, or federal law.

Keywords: Glympse Bio, Cambridge , Director, Translational Research, Executive , Cambridge, Massachusetts

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