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Vice President Translational Science

Company: NextPoint Therapeutics, Inc.
Location: Cambridge
Posted on: June 24, 2022

Job Description:

SummaryNextPoint Therapeutics is an exciting early-stage Boston-area startup company working at the frontier of immuno-oncology. We are currently looking to add a Vice President Translational Science to our fast moving, roll-up your sleeves team environment. Reporting to the Chief Scientific Officer, the Vice President will build our Translational Medicine capability, responsible for managing research activities bridging from discovery to clinical development. The successful candidate will have a deep scientific knowledge and experience with oncology and immuno-oncology targets, biomarkers and animal models. The candidate will collaborate with Research and Clinical Development to develop and refine NextPoint's clinical translational strategy and drive its effective implementation to support our clinical programs.Responsibilities

  • Drive the clinical biomarker function to identify indications, support patient stratification and to inform on mechanism of action; develop, qualify, and execute biomarker assays with the most appropriate technical platforms to advance and support immune-oncology therapeutics to the clinic.
  • Independently design, execute and manage translational research activities from discovery through clinical development
  • Develop and implement research and clinical-level assays, along with data analysis, interpretation, and report generation
  • Work closely with the research and preclinical team to identify novel biomarkers and translate to the clinical setting
  • Integrate biomarker and clinical data to guide patient stratification
  • Manage CROs responsible for the generation of both exploratory and clinical biomarker data
  • Contribute to clinical documents such as, INDs, IBs, regulatory submissions, laboratory manuals and clinical protocols
  • Function as a scientific thought leader inside the company for cutting edge biomarker approachesEducation and Qualifications
    • PhD or MD in cancer biology, immunology, genomics, biochemistry, or molecular/cellular biology
    • 7+ years of pharmaceutical or biotechnology industry experience in oncology or cancer immunotherapy with an emphasis on translational research, clinical biomarkers, and monoclonal antibodies
    • Proven track record of transitioning biomarkers from the bench to the clinic
    • Strong knowledge of immuno-oncology and associated biomarker approaches
    • Experience managing CROs
    • Technical expertise in IHC, RNAscope, flow cytometry, genetics (including ctDNA), RNA-Seq, NanoString, qPCR and ELISAs
    • Proven success with filing INDs and supporting clinical trials
    • Competency with bioinformatic datasets and experience collaborating with bioinformaticians to analyze publicly available datasets
    • Excellent communication and interpersonal skills, personal integrity, professional manner, and ability to gain respect and develop good working relationships with cross functional personnel at all levels
    • Ability to balance multiple stakeholders and projects simultaneously, and able to operate with high accountability and under tight deadlines
    • Forward looking thinker, who actively seeks opportunities and proposes solutions with strong decision-making capability
    • A collaborator who communicates in an open, clear, complete, timely and consistent manner who listens effectively and invites response and discussion

Keywords: NextPoint Therapeutics, Inc., Cambridge , Vice President Translational Science, Executive , Cambridge, Massachusetts

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