Vice President Translational Science
Company: NextPoint Therapeutics, Inc.
Location: Cambridge
Posted on: June 24, 2022
Job Description:
SummaryNextPoint Therapeutics is an exciting early-stage
Boston-area startup company working at the frontier of
immuno-oncology. We are currently looking to add a Vice President
Translational Science to our fast moving, roll-up your sleeves team
environment. Reporting to the Chief Scientific Officer, the Vice
President will build our Translational Medicine capability,
responsible for managing research activities bridging from
discovery to clinical development. The successful candidate will
have a deep scientific knowledge and experience with oncology and
immuno-oncology targets, biomarkers and animal models. The
candidate will collaborate with Research and Clinical Development
to develop and refine NextPoint's clinical translational strategy
and drive its effective implementation to support our clinical
programs.Responsibilities
- Drive the clinical biomarker function to identify indications,
support patient stratification and to inform on mechanism of
action; develop, qualify, and execute biomarker assays with the
most appropriate technical platforms to advance and support
immune-oncology therapeutics to the clinic.
- Independently design, execute and manage translational research
activities from discovery through clinical development
- Develop and implement research and clinical-level assays, along
with data analysis, interpretation, and report generation
- Work closely with the research and preclinical team to identify
novel biomarkers and translate to the clinical setting
- Integrate biomarker and clinical data to guide patient
stratification
- Manage CROs responsible for the generation of both exploratory
and clinical biomarker data
- Contribute to clinical documents such as, INDs, IBs, regulatory
submissions, laboratory manuals and clinical protocols
- Function as a scientific thought leader inside the company for
cutting edge biomarker approachesEducation and Qualifications
- PhD or MD in cancer biology, immunology, genomics,
biochemistry, or molecular/cellular biology
- 7+ years of pharmaceutical or biotechnology industry experience
in oncology or cancer immunotherapy with an emphasis on
translational research, clinical biomarkers, and monoclonal
antibodies
- Proven track record of transitioning biomarkers from the bench
to the clinic
- Strong knowledge of immuno-oncology and associated biomarker
approaches
- Experience managing CROs
- Technical expertise in IHC, RNAscope, flow cytometry, genetics
(including ctDNA), RNA-Seq, NanoString, qPCR and ELISAs
- Proven success with filing INDs and supporting clinical
trials
- Competency with bioinformatic datasets and experience
collaborating with bioinformaticians to analyze publicly available
datasets
- Excellent communication and interpersonal skills, personal
integrity, professional manner, and ability to gain respect and
develop good working relationships with cross functional personnel
at all levels
- Ability to balance multiple stakeholders and projects
simultaneously, and able to operate with high accountability and
under tight deadlines
- Forward looking thinker, who actively seeks opportunities and
proposes solutions with strong decision-making capability
- A collaborator who communicates in an open, clear, complete,
timely and consistent manner who listens effectively and invites
response and discussion
Keywords: NextPoint Therapeutics, Inc., Cambridge , Vice President Translational Science, Executive , Cambridge, Massachusetts
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