Senior Director, Biomarker Development - Translational Sciences

Company: Versant NewCo
Location: Cambridge
Posted on: May 13, 2022

Job Description:

Senior Director, Biomarker Development - Translational Sciences
Location: Cambridge MA

We are a Cambridge-based VC-backed stealth biotech focused on discovering and developing the next generation of precision oncology small molecule medicines. We are advancing drug discovery programs based on a platform that combines insights into cancer biology, structural biophysics and innovative chemical biology to identify and characterize novel drivers and druggable protein domains. Our team is seeking a highly motivated and enthusiastic scientist to lead the implementation of biomarker and diagnostic strategies for our frontrunner franchises. As the founding member of the Translational Sciences group, the candidate will influence indication selection, early clinical development, and companion diagnostic (CDx) regulatory path. This role will involve significant interaction and collaboration across the R&D organization as well as with external partners. The position offers the opportunity to contribute to both drug discovery and clinical projects in an innovative and fast-paced team environment with tremendous growth opportunity.

Principal Duties and Responsibilities:
- Serve as biomarker lead for preclinical and clinical stage oncology programs by independently formulating strategies for the discovery, development, and implementation of biomarkers for ultimate use in clinical settings
- Develop and direct scientifically accurate assays to translate preclinical data into meaningful clinical biomarkers for advancing molecular glue candidates
- Collaborate cross-functionally (e.g., target biology, translational research, nonclinical and clinical development) to ensure successful operational execution of biomarker plans
- Establish outsourcing of biomarker assays as needed and develop a plan for internal biomarker capabilities
- Communicate data and strategies effectively to key stakeholders, including internal team members,senior management, and external partners

Desired Skills and Experience :
- PhD or equivalent in translational medicine, biology, pharmacology or related discipline with 8-10+ years of relevant experience in the biotech/industry and/or academic institutions
- Experience in translating disease biology and the pharmacology of therapeutic agents into clinical biomarker strategies that address key questions during clinical development and impact clinical decision-making across multiple projects
- Demonstrated ability to use strong science to guide strategic direction
- Proven track record for striving for high level of inter-disciplinary problem solving, innovation and scientific excellence
- Demonstrated experience managing and leading teams, both directly and in matrix organizations
- Experience working with CROs for the development, transfer and deployment of diagnostic assays preferred, including budget management
- Experience with companion diagnostic/diagnostic development preferred (CDRH experience a plus, including pre-sub, IDE and/or PMA interactions)
- Strong strategic and critical thinking skills, with a demonstrated ability to analyze, interpret, and clearly communicate (written and oral) complex biomarker data and its impact on program and regulatory strategy

Interested Candidates should forward a cover letter and CV to careers@nestedtx.com

We are a Cambridge-based VC-backed stealth biotech focused on discovering and developing next generation precision oncology small molecule medicines. We are advancing drug discovery programs based on a platform that combines insights in cancer biology, structural biology, biophysics and chemical biology to identify and characterize novel druggable domains of protein targets. We are targeting pathways comprising the heartland of cancer research, including novel mechanisms regulated by the transcription factors.

Keywords: Versant NewCo, Cambridge , Senior Director, Biomarker Development - Translational Sciences, Executive , Cambridge, Massachusetts