Associate Director, Preclinical Sciences Lead, Autoimmunity/Tolerance
Company: Repertoire Immune Medicines
Posted on: January 12, 2022
Associate Director, Preclinical Sciences Lead,
Autoimmunity/Tolerance Repertoire Immune Medicines is a
clinical-stage biotechnology company working to unlock and direct
the remarkable power of the human immune system to prevent or treat
cancer, as well as autoimmune and infectious disease. The company
is founded on the belief that the repertoire of T cell receptor
(TCR)-antigen codes that drive health and disease represents one of
the greatest opportunities for innovation in medical science.
Repertoire scientists created and developed the DECODE and DEPLOY
suite of technologies, which allow in-depth characterization of
TCR-antigen pairs, and the ability to rationally design and develop
novel targeted immune medicines. From its sites in Cambridge,
Mass., and Zurich, Switzerland, Repertoire's team of more than 120
is creating a new category of immune medicines enabled from its
DECODE discovery platform. The company's first product in the
clinic is a novel multiclonal T cell therapy consisting of T cells
derived from the peripheral blood, activated against a curated set
of antigens, and armed with a proprietary cytokine. Repertoire is
in clinical-stage immuno-oncology development today, targeting
metastatic solid tumors. In the field of autoimmunity, Repertoire
is currently using its proprietary platform to discover novel
epitopes and TCRs from patients with type 1 diabetes. The company
is also using its DECODE platform to discover infectious disease
antigens and responding T cell clones. Role Overview Repertoire is
looking for an experienced and independent Associate Director to
join us as a preclinical science team leader in our autoimmune
tolerance platform group. The successful candidate will provide
thought leadership and manage a team of in vivo and in vitro
scientists in establishing and employing insightful models towards
the demonstration of novel antigen specific therapies for the
treatment of autoimmune disease. This is a key role that will help
drive the value of our proprietary DECODE TM discovery engine via
an indispensable contribution to the development of novel
therapeutics. Reporting directly to the head of the autoimmune
tolerance platform group, the candidate will lead the preclinical
sciences team, working closely with the rest of the tolerance
platform group, which includes a nanotechnology team that is
responsible for therapeutic technology development, as well as the
discovery leads that are responsible for discovery and validation
of T cell targets in autoimmune diseases. Significant opportunities
for innovation exist, both in identifying the immune regulatory
strategies necessary to achieve tolerance in antigen specific T
cell modulation, as well as in establishing the mechanism of action
of novel tolerizing therapies. Additional integrations and
interfaces will be across the broader DECODE TM technology
ecosystem and into adjacent technology teams working on
Repertoire's other therapeutic modalities. Strong interpersonal,
verbal, and written communication skills along with experimental
rigor and scientific curiosity are key! The ability to work in a
matrixed team environment and adaptability to evolving priorities
are a must. Key Responsibilities
- Take the lead on preclinical sciences for the development of
autoimmune directed antigen specific therapeutic modalities.
Contribute to developing project/program strategy and lead the
implementation and execution of that strategy. Engage as a core
team member working closely with technology and antigen discovery
- Serve as the subject matter expert for murine pharmacology
models for the autoimmune tolerance platform, establishing new
models as needed either internally or externally.
- Lead efforts for the identification and screening of
immunomodulatory payloads to modulate APCs and T cells.
- Establish transgenic mouse models to support the in vivo
validation of autoimmune T cell epitopes discovered via our DECODE
TM discovery engine.
- Contribute to cross functional efforts to research, evaluate,
and prioritize therapeutic disease areas for internal candidate
- Prepare presentations for internal and external stakeholders
- Be an active participant in building the company and group
- Ph.D. in Immunology, Autoimmune Biology, or adjacent
- 8+ years post graduate experience in biotech/pharma industry or
academia (experience in industry is strongly preferred).
- Extensive hands-on experience with murine pharmacology models.
Familiarity with transgenic humanized mouse models and autoimmune
disease models is a significant plus. Familiarity with antigen
specific T cell models is a plus.
- Experience with drug discovery and preclinical drug development
practices from discovery to IND.
- Experience leading teams of scientists including Ph.D. level
staff and beyond.
- Strong leadership, personal organizational, multi-tasking, and
- Balance creativity and science with delivery on key milestones
within defined timelines. Repertoire is committed towards social
responsibility and developing an inclusive culture. Much as the
power of the immune system lies in the diversity of T and B cells,
we believe that our work requires the creativity and ingenuity of a
diverse workforce, and we are committed to pursuing that in all
facets of the work experience at Repertoire. We will continue to
educate ourselves about the inequities and barriers present in our
society and act as a company where we can make a difference.
Repertoire is proud to be an Equal Opportunity Employer. You have
been redirected to a Repertoire Immune Medicines job page
Keywords: Repertoire Immune Medicines, Cambridge , Associate Director, Preclinical Sciences Lead, Autoimmunity/Tolerance, Executive , Cambridge, Massachusetts
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