Translational Science Bioinformatics Associate Director

Company: Cleveland Clinic Lerner College Of Medicine
Location: Cambridge
Posted on: April 6, 2021

Job Description:

American Nursing Informatics Association (ANIA)

• Translational Science Bioinformatics Associate Director Translational Science Bioinformatics Associate Director Developing innovative therapies is one of the most challenging, most essential and personally rewarding fields in science. This is the most exciting time to be a part of Astellas, a company with a uniquely collaborative and patient-focused culture. There's something special about working at Astellas. It's reflected in our focus on the people we serve, the way we treat each other and the results we achieve together as a company. Astellas is announcing a Bioinformatics Associate Director opportunity in Cambridge, MA. Purpose & Scope: Responsible for providing bioinformatics expertise to drug target selection, translational research, and patient selection strategy for multiple drug discovery/development programs. Perform hands-on bioinformatics analyses on internal and external data sets related to Astellas/partner discovery and development programs. Also responsible for generating analysis plans and reports related to the above analyses.
  • Utilize state of the art bioinformatics methods and available internal and external data to address translational questions related to indication selection, patient segmentation, and biomarker identification
  • Select the appropriate data sets and analytical approaches for drug target identification and validation to support cancer cell therapy and other discovery research
  • Develop new analysis tools and databases to meet project needs
  • Identify and evaluate external resources (CRO/academic collaborator) to complement internal capabilities
  • Ensures that the analyses by the CROs/academic collaborators are accurate and reliable Quantitative Dimensions:
    • Collaborate with Discovery Research, Translational Science and other Development personnel involved in pre-candidate nomination projects
    • Lead bioinformatics analyses to support drug target identification, translational research and clinical biomarker analyses
    • Responsible for assuring that all relevant data are used for indication and patient selection (including biomarkers) to support clinical development Organizational Context:
      • Reports to Head of Translational Science
      • Matrixed relationship to colleagues on the Global Development Project Team, Cancer Cell Therapy, and Drug Discovery Research
      • Manages external partnerships that support biomarker development activities for projects in immunology and immuno-oncology Requirements Qualifications: Required:
        • Ph.D. in computational biology, bioinformatics, or other biomedical sciences with a minimum of five years' experience in applying bioinformatics approaches to drug discovery/development, preferably in a biopharma setting
        • Strong publication record in peer reviewed journals
        • Demonstrated experience in cancer genomics and omics data analyses, including experience with developing pipelines for next-generation sequencing data analysis and QC
        • Strong capability in designing and performing bioinformatics analyses to address translational questions, and to obtain insight on patient segmentation and biomarker selection
        • Excellent programming skills (including R, Python, SAS) and deep-knowledge for statistical analysis and machine learning
        • Experience with data visualization using web application such as Shiny/plotly
        • Experience with highly parallel, clustered, or supercomputing systems.
        • Strong communication skills (oral, written, and presentations) and cross-functional teamwork are essential Preferred
          • Experience in analyzing single cell sequencing data and proteomics data
          • Experience in maintaining in-house Laboratory Informatics Management System (LIMS)
          • Administration experience of clustered-computing systems
          • Experience with human genetics data and real world genomics/transcriptomics data. #LI-VB Equal Opportunity Employer Minorities/Women/Protected Veterans/Disabled Category Research and Development Job Information
            • Job ID: 55760350
            • Location:
              Cambridge, Massachusetts, United States
            • Position Title: Translational Science Bioinformatics Associate Director Astellas Pharma US, Inc., is a U.S. affiliate of Tokyo-based Astellas Pharma Inc. Located in Northbrook, Illinois, the company serves as the headquarters for the U.S. and employs nearly 1,200 people. Astellas is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceutical products.Our commitment to changing tomorrow is measured not only by our focus on bringing innovative and effective new medicines to patients and physicians, but al... East Holly Avenue, Box 56 Pitman, NJ 08071

Keywords: Cleveland Clinic Lerner College Of Medicine, Cambridge , Translational Science Bioinformatics Associate Director, Executive , Cambridge, Massachusetts