Scientist / Principal RA, Cell Engineering
Company: Clade Therapeutics
Posted on: May 13, 2022
Scientist / Principal RA, Cell Engineering
About Clade Therapeutics
Clade Therapeutics is a well-funded, early-stage cell therapy
company developing novel cell-based medicines for the treatment of
cancer and other devastating diseases. The Company, located in
Kendall Square, was founded by an exceptional group of academic
leaders and successful bioentrepreneurs. Clade works at the
convergence of stem cell biology, immunology, regenerative
medicine, and gene editing to create the next-generation of stem
We are passionate about delivering on the promise of cellular
therapy, shaping the future of cellular medicine, and delivering
new therapies to millions of patients.
Clade seeks a highly motivated individual to join our growing
Immunology team in Cambridge, MA. The successful candidate will
have demonstrated bench experience in iPSC cell engineering and
molecular biology. This individual will join a team of scientists
to engineer and characterize novel immune cell therapies derived
from induced Pluripotent Stem Cells (iPSC) for the treatment of
cancer and other diseases. Specific responsibilities will be to
generate engineered cell lines and to characterize them by
molecular, genomic, and proteomic means. This is an outstanding
opportunity to be part of a world class team, bringing a new class
of cellular therapies to patients.
This person must be self-motivated, collaborative, thrive in a fun
/ dynamic culture, and be steadfast in the commitment to advance
cutting-edge cellular therapies to improve patients' lives.
If interested and qualified, please include Requisition #2022-12 in
the subject line when emailing resume to : firstname.lastname@example.org
Develop and maintain novel engineered cell lines.
Design and production of gene editing constructs, including
plasmids, gRNAs, RNPs, lentiviruses and mRNAs.
Execute assays for assessing on-target and off-target editing
activity by ICE, flow cytometry, ELISA, qPCR, digenome-seq,
amp-seq, western blot, and others.
Analyze data and effectively communicate results to peers and
Document experimental data in electronic laboratory notebooks
(ELNs) in a timely and accurate manner.
Collaborate with team members internally and externally.
Attend and actively contribute to the scientific discussion at
laboratory team meetings.
Effectively present data and other scientific information to
Contribute to Company's IP filings resulting from research
PhD degree in molecular biology, engineering or related discipline
and 1+ years of relevant experience or BS/MS degree and 9+ years of
Proficient, working knowledge of viral/non-viral gene delivery
methods as well as molecular biology experience
Hands-on experience with molecular biology techniques including
plasmid construction, cloning, and sequence analysis is
Hands-on experience with mammalian cell culture and cell line
generation is required.
Previous experience in iPSCs, cell therapy, gene therapy, and/or
immunology is preferred.
Highly organized and collaborative work style; ability to maintain
detailed documentation in an electronic lab notebook.
Demonstrated experience working effectively with peers in a
results-oriented research environment.
Patients First - Proactively and constructively engage to deliver
results for those in need. "Begin with patient's success in
Communication and Respect - Foster open exchange with colleagues
and collaborators. Seek to understand and treat people with
courtesy. "Better together"
Integrity & Excellence - Act honestly and ethically to seek the
truth. Courageously doing the right thing - take smart risks and
make tough decisions in pursuit of exceptional outcomes. "Get it
If interested and qualified, please include Requisition # 2022-12
in the subject line when emailing resume to :
Clade Therapeutics, Inc. is committed to equal employment
opportunity and non-discrimination for all employees and qualified
applicants without regard to a person's race, gender, age,
religion, national origin, disability, veteran status, sexual
orientation or any characteristic protected under applicable
Keywords: Clade Therapeutics, Cambridge , Scientist / Principal RA, Cell Engineering, Engineering , Cambridge, Massachusetts
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