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Process Development Engineer

Company: CRISPR Therapeutics
Location: Cambridge
Posted on: February 25, 2021

Job Description:

Job SummaryAs part of the Regenerative Medicine Group, we are seeking a Engineer II/Engineer III to join an exciting, fast-growing and well-financed company. Successful candidates will be integral in developing stem cell-derived therapies for regenerative medicine. The role will be responsible for development of cell therapy production platforms and will participate in development of advanced cell processing and culture systems. Successful candidates will have strong process development/scale-up skills for expansion and differentiation of pluripotent stem cells in bioreactors. The position requires enthusiasm, passion, self-motivation, attention to detail, and a desire to create novel therapies for patients.Responsibilities* Proactive approach to work and entrepreneurial spirit are key.* Independently execute bioreactor stem cell culture experiments. * Support establishing cellular process parameters and process scale-up activities. * Culture of human pluripotent stem cells including maintenance, expansion, * Perform and analyze in vitro cellular assays such as cell counts, flow cytometry and imaging.* Apply DOE/QBD principals to process development and process optimization.* Maintain clear and complete experimental records. * Support drafting and revising protocols and SOPs and regulatory sections and fillings (i.e. IND).Minimum Qualifications* M.S. in Chemical/Biochemical Engineering or related discipline with minimum 1 year of relevant industrial work; or BS in Chemical/Biochemical Engineering or related discipline and 3+ years of relevant experience.* Experience working with cell processing devices and bioreactors is very helpful.* Experience with mammalian cell culture. * Process development experience in a bio-pharmaceutical setting working with interdisciplinary and cross-cultural teams.* Ability to communicate effectively with a diverse range of scientists and engineers.* Ability to work independently as well as part of a results-oriented research team.* Highly organized with significant attention to detail.Preferred Qualifications* M.S. in Chemical/Biochemical Engineering or related discipline with 2+ years of relevant industrial work.* Extensive experience with operation of cell culture bioreactor systems ideal.* Experience developing processes for early phase clinical products.* Experience with Design of Experiments (DOE) for process optimization. * Experience with pluripotent stem cell culture.CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy

Keywords: CRISPR Therapeutics, Cambridge , Process Development Engineer, Engineering , Cambridge, Massachusetts

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