Scientist/Senior Scientist, Genome Engineering
Company: BlueRock Therapeutics
Location: Cambridge
Posted on: February 16, 2021
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Job Description:
Senior Scientist, Genome EngineeringWho is BlueRock?BlueRock
Therapeutics, a wholly-owned and independently operated subsidiary
of Bayer AG, is a leading engineered cell therapy company using its
unique cell+gene platform to direct cellular differentiation and
genetically engineer cells to create a new generation of cellular
medicines that address large patient populations suffering from
neurological, cardiovascular, and immunology diseases.The
convergence of cell biology and genetic engineering is creating
fundamental new ways to impact disease. Founded in 2016 to
capitalize on these technological breakthroughs, we are advancing
our novel cell+gene platform to develop, manufacture, and deliver
an entirely new generation of authentic and engineered cell
therapies across three therapeutic areas neurology, cardiology, and
immunology.What Are We Doing?Our foundational science harnesses the
ability to create and then direct the differentiation of universal
pluripotent stem cells into authentic, functional cells that can be
used as allogeneic cellular therapies to treat a broad array of
diseases. We can also further engineer these cells, enabling them
to produce enzymes, antibodies, and other proteins for additional
therapeutic benefit.We are passionate about delivering on the
promise of cellular and gene therapy, shaping the future of
cellular medicine, and delivering new therapies to millions of
patients with treatment options.We are seeking individuals who are
collaborative, thrive in a fun and dynamic culture, and are
steadfast in the commitment to advance cutting-edge cellular
therapies to impact patients' lives.Description Of PositionThe
Cambridge, MA, USA site is seeking a Sr. Scientist for the Genome
Engineering pipeline that will report to the Vice President of
Platform Development. The incumbent will manage a dynamic and
progressive team pioneering the design and production of
genome-modified therapeutic cells from human pluripotent stem cells
(hPSCs). The candidate will lead a small team that will work
closely with Immunology to help design and build cell lines for
Immune Evasion and the Immune Cell Therapy programs. On the
platform side, the ideal candidate will create an automated
solution to rapidly build and test new genome
designs.Responsibilities* Execute in vitro experiments to
characterize and cultivate hPSCs and their derivatives.* Assist in
the design and construction of plasmids for genetic modification.*
Apply gene editing technologies including CRISPR/Cas9 in hPSCs.*
Perform DNA/RNA-based, cell-based, flow cytometric,
immunofluorescence and other analytical assays as required.*
Analyze and document experimental data in electronic laboratory
notebooks in a timely and accurate manner in accordance with the
company quality management system.* Be responsible for data
generation, collection, interpretation and communication of
results.* Prepare and follow standard operating procedures, batch
records and other process documentation.* Attend and present
scientific data to colleagues at internal meetings.Minimum
Requirements* Ph.D. in immunology, cell biology, molecular biology,
genetics or related discipline, with 5-8 years laboratory research
or industry experience.* Experience with molecular cloning and gene
editing technologies.* Experience with cell characterization
technologies including PCR, DNA sequencing, qPCR, flow cytometry
and immunofluorescence.* Industry experience preferred.* Experience
with human pluripotent stem cell or mammalian cell culture
preferred.* Experience with high-throughput equipment and methods
preferred.* Experience with hPSC transfection/nucleofection
techniques preferred.* Experience with DNA design software is
preferred.* Excellent analytical, problem solving and
organizational skills.* Strong written and verbal communications
skills.Equal Opportunity Workplace At BlueRock, we welcome and
support differences and diversity and we are proud to be an equal
opportunity workplace. Please let us know if you require
disability-related accommodation or other grounds protected by
human rights legislation during the recruitment process so that we
can work with you to meet your needs.
Keywords: BlueRock Therapeutics, Cambridge , Scientist/Senior Scientist, Genome Engineering, Engineering , Cambridge, Massachusetts
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