Principal Scientist, Chemical Biology
Company: Civetta Therapeutics
Location: Cambridge
Posted on: May 16, 2022
Job Description:
Location: US-MA-CambridgeID: 2021-1636# of Openings : 1Category:
Research & DevelopmentAddress: 10 Wilson RoadOverviewCIVETTA
THERAPEUTICSCambridge, MAPrincipal Scientist, Chemical Biology
OverviewCivetta Therapeutics (located in Cambridge, MA) is
developing novel therapeutics through small molecule targeting of
beta-propeller domain proteins. Beta-propellers are a class of
highly conserved structural proteins that are implicated in a range
of indications, including multiple types of cancer,
neurodegenerative and metabolic diseases. Backed by Deerfield
Management, Civetta was founded by William Sellers (Broad Institute
and Dana-Farber Cancer Institute) and Eric Fischer (Dana Farber
Cancer Institute and Harvard Medical School) with the mission to
leverage the wide array of biologic functions in which propeller
proteins participate to discover impactful new medicines for
patients. We are building a team of talented, dedicated scientists
who share our vision and our passion to discover groundbreaking new
drugs to treat some of the most difficult diseases, including
cancer. If you are an accomplished life sciences professional that
can bring significant energy, passion and expertise to the team, we
welcome the opportunity to consider you for a position in this
exciting, new company committed to thorough, mechanistically-driven
science. The positionWe are seeking an accomplished Chemical
Biologist to propel our efforts, using chemical probes to explore
propeller protein function and deliver new propeller-targeted
medicines for patients. This newly created position is highly
visible within the organization, and to our scientific leadership
team. This is an excellent opportunity for an experienced
individual looking to work in a fast-paced, dynamic biotech
environment. ResponsibilitiesKey Responsibilities:
- The ideal candidate will contribute to world class chemical
biology capabilities to enable Civetta's beta-propeller platform
to:
- develop protocols, experimentally design, perform and analyze
proteomics-based photocrosslinking pulldowns, chemoproteomics to
identify molecular targets and pathways as key drivers in disease
relevant cell lines.
- perform target engagement techniques to quantify propeller
interactions with small molecules in cells.
- study of protein complexes through proximity labeling
techniques (BioID, APEX etc..) or immunoprecipitation
- Enable electrophilic and photoreactive fragment discovery.
- The applicant must be able to work collaboratively as a member
of cross-functional teams through regular attendance of project
team meetings, presentation of their data and contribution to the
overall success of the project.
- Establish and manage relations with external collaborations
when and as needed.
- Scope and internalize new methods for target identification and
mechanistic studies.
- Proteomics sample preparation is a
plus.QualificationsQualifications
- D. in chemical biology, biochemistry, proteomics, or related
discipline with 7+ years of industry experience or
Master's/Bachelor's degree with 10+ years of experience.
- Experience designing and implementing experiments to enable
ligand discovery, target identification and/or target validation
using chemical probes, mass spectrometry and related tools.
- Experience with basic biology and biochemistry techniques, such
as cell culture, cell lysing, protein extraction, and
quantification
- Self-motivated and creative thinker to solve challenging
biological and technical problems in a fast-paced dynamic team
environment
- Spirit of collaborative research to enable success in a team
environment with exceptional interpersonal and communication
skills, and ability to effectively present data within the company
and to other stakeholders.
- Experience working with CRO and internal resources to solve
problems and drive progress.
- Adept at leading and working effectively within motivated
cross-functional scientific teams to deliver project goals within
timelines.Civetta Therapeutics provides equal employment
opportunities (EEO) to all employees and applicants for employment
without regard to religion, race, creed, color, sex, sexual
orientation, alienage or citizenship status, national origin, age,
marital status, pregnancy, disability, veteran or military status,
predisposing genetic characteristics or any other characteristic
protected by applicable federal, state or local law.Notice to
Third-Party Recruiters/Staffing Agencies: Recruitment is managed
through Civetta Therapeutics' Human Resources department. Resumes
will only be accepted from staffing agency/recruiters if there is a
signed contract in place. Recruiters are requested to not contact
our hiring managers or employees directly to inquire about open
positions or to present candidates. In the event a staffing
agency/third-party recruiter submits a resume without a contract in
place, the candidate submitted will be considered unsolicited and
treated as if the candidate submitted their resume directly to
Civetta, and no fee/payment will be paid. Recruiters interested in
working with Civetta Therapeutics can submit their information to ,
and we will contact you if
needed.CTx-1104PM18#LI-DNIPI177616299
Keywords: Civetta Therapeutics, Cambridge , Principal Scientist, Chemical Biology, Education / Teaching , Cambridge, Massachusetts
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