Principal Scientist, Clinical Biomarkers, Translational Medicine
Company: American College of Clinical Pharmacology
Location: Cambridge
Posted on: May 12, 2022
Job Description:
American College of Clinical Pharmacology
- Principal Scientist, Clinical Biomarkers, Translational
MedicinePrincipal Scientist, Clinical Biomarkers, Translational
Medicine Principal Scientist, Clinical Biomarkers, Translational
Medicine Cambridge, MA Requisition Number: 108 Blueprint Medicines
is a global precision therapy company that invents life-changing
therapies for people with cancer and hematologic disorders.
Applying an approach that is both precise and agile, we create
medicines that selectively target genetic drivers, with the goal of
staying one step ahead across stages of disease. Since 2011, we
have leveraged our research platform, including expertise in
molecular targeting and world-class drug design capabilities, to
rapidly and reproducibly translate science into a broad pipeline of
precision therapies. Today, we are delivering approved medicines
directly to patients in the United States and Europe, and we are
globally advancing multiple programs for genomically defined
cancers, systemic mastocytosis, and cancer immunotherapy. What will
you do? The Translational Medicine team at Blueprint is seeking a
highly motivated Principal Scientist/Associate Director dedicated
to clinical biomarker development, implementation, and
interpretation to help advance our oncology pipeline. The
successful candidate will be responsible for developing and
executing integrated biomarker strategies utilizing state of the
art technologies. A strong understanding of tumor biology and the
ability to analyze and interpret complex data sets will be a key
strength. What will be your responsibilities?
- Define and execute translational and biomarker strategies for
Blueprint's clinical-stage oncology programs with a focus on
mechanism of action, target engagement, establishment of
PK/PD/efficacy relationships, patient selection strategies and
understanding mechanisms of intrinsic and acquired resistance.
- Ensure that clinical biomarker plans are developed and
implemented efficiently and aligned with the strategic needs of the
program.
- Manage external biomarker analysis at specialty CROs including
qualification, budgeting, timelines, and oversight of execution
during trial conduct.
- Contribute to the development of clinical protocols, laboratory
manuals, regulatory submissions, abstracts, and publications.
- Analyze, interpret, and present integrated clinical biomarker
results and implications for clinical strategy to internal and
external stakeholders.
- Effectively collaborate across internal functions including
discovery, translational, clinical pharmacology, clinical
development, data management and regulatory affairs to ensure
successful execution in the clinic.
- Clearly communicate translational strategies, timelines,
dependencies, risks, and mitigations to team members.
- Evaluate new technologies and partner with external
collaborators to enable exploratory biomarkers. What basic
qualifications do we require?
- Ph.D., M.D./Ph.D. or equivalent advanced biology degree and 3-5
years of industry experience in clinical biomarker execution in the
oncology setting. What additional qualifications are we seeking?
- Demonstrated knowledge of clinically relevant biomarker
approaches across a range of technology platforms. -
- Experience working with central laboratories and contract
research organizations supporting specialized biomarker
analysis.
- Familiarity with working in the GxP environment with a focus on
quality.
- Familiarity with the technical and regulatory aspects of
companion diagnostic development.
- Exceptional organizational and recordkeeping skillsets, with
strong attention to detail.
- Team player, with good communication skills.
- Excellent communication skills and ability to work in a
fast-paced matrixed team setting.
- Commitment to Blueprint Medicines' Core Values: Patients First,
Thoughtfulness, Urgency, Trust, Optimism As a biotechnology
organization, it is -our responsibility -to do everything we can to
safeguard -the -health and safety -of our workforce, -our
communities, -and -the patients we -serve. That is why we require
all employees to be fully vaccinated against COVID-19, unless we
approve an exemption through a reasonable accommodation for
certified health reasons or sincerely held religious beliefs.
Accommodation requests for either of these reasons should be made
to -TotalRewards@blueprintmedicines.com. Equity, Diversity,
Inclusion and Affirmative Action At Blueprint Medicines, we foster
a culture of equity, diversity and inclusion. A proud Equal
Employment Opportunity and Affirmative Action employer, we consider
all qualified applicants without regard to race, color, sex, gender
identity or expression, sexual orientation, age, religion, national
origin, ancestry, ethnicity, disability, veteran status, genetic
information, or any other characteristic protected under applicable
law. We are also an E-Verify Employer. We will make reasonable
accommodations, absent undue hardship, for qualified individuals
with known disabilities. If you are an individual with a disability
who requires an accommodation with the hiring process or to perform
any essential functions of the position for which you are applying,
please reach out to TotalRewards@blueprintmedicines.com. - We don't
think in small steps. We think in giant leaps. We are driven by the
pursuit of new ideas, new innovations, and new ways of thinking. We
know that what each and every one of us matters and that our
success depends on our ability to work together in a diverse
community. We believe we are at our best as a company when our
employees are thriving and we foster a culture that provides
opportunities to grow and develop professionally, while also having
fun. Job Information
- Job ID: 62511325
- Location:
Cambridge, Massachusetts, United States
- Position Title:Principal Scientist, Clinical Biomarkers,
Translational MedicinePlease refer to the company's website or job
descriptions to learn more about them. Associate Director, Clinical
Pharmacology Cambridge, Massachusetts, United States 25 days ago
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Keywords: American College of Clinical Pharmacology, Cambridge , Principal Scientist, Clinical Biomarkers, Translational Medicine, Education / Teaching , Cambridge, Massachusetts
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