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Principal Scientist, Clinical Biomarkers, Translational Medicine

Company: American College of Clinical Pharmacology
Location: Cambridge
Posted on: May 12, 2022

Job Description:

American College of Clinical Pharmacology

  • Principal Scientist, Clinical Biomarkers, Translational MedicinePrincipal Scientist, Clinical Biomarkers, Translational Medicine Principal Scientist, Clinical Biomarkers, Translational Medicine Cambridge, MA Requisition Number: 108 Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and hematologic disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, to rapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for genomically defined cancers, systemic mastocytosis, and cancer immunotherapy. What will you do? The Translational Medicine team at Blueprint is seeking a highly motivated Principal Scientist/Associate Director dedicated to clinical biomarker development, implementation, and interpretation to help advance our oncology pipeline. The successful candidate will be responsible for developing and executing integrated biomarker strategies utilizing state of the art technologies. A strong understanding of tumor biology and the ability to analyze and interpret complex data sets will be a key strength. What will be your responsibilities?
    • Define and execute translational and biomarker strategies for Blueprint's clinical-stage oncology programs with a focus on mechanism of action, target engagement, establishment of PK/PD/efficacy relationships, patient selection strategies and understanding mechanisms of intrinsic and acquired resistance.
    • Ensure that clinical biomarker plans are developed and implemented efficiently and aligned with the strategic needs of the program.
    • Manage external biomarker analysis at specialty CROs including qualification, budgeting, timelines, and oversight of execution during trial conduct.
    • Contribute to the development of clinical protocols, laboratory manuals, regulatory submissions, abstracts, and publications.
    • Analyze, interpret, and present integrated clinical biomarker results and implications for clinical strategy to internal and external stakeholders.
    • Effectively collaborate across internal functions including discovery, translational, clinical pharmacology, clinical development, data management and regulatory affairs to ensure successful execution in the clinic.
    • Clearly communicate translational strategies, timelines, dependencies, risks, and mitigations to team members.
    • Evaluate new technologies and partner with external collaborators to enable exploratory biomarkers. What basic qualifications do we require?
      • Ph.D., M.D./Ph.D. or equivalent advanced biology degree and 3-5 years of industry experience in clinical biomarker execution in the oncology setting. What additional qualifications are we seeking?
        • Demonstrated knowledge of clinically relevant biomarker approaches across a range of technology platforms. -
        • Experience working with central laboratories and contract research organizations supporting specialized biomarker analysis.
        • Familiarity with working in the GxP environment with a focus on quality.
        • Familiarity with the technical and regulatory aspects of companion diagnostic development.
        • Exceptional organizational and recordkeeping skillsets, with strong attention to detail.
        • Team player, with good communication skills.
        • Excellent communication skills and ability to work in a fast-paced matrixed team setting.
        • Commitment to Blueprint Medicines' Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism As a biotechnology organization, it is -our responsibility -to do everything we can to safeguard -the -health and safety -of our workforce, -our communities, -and -the patients we -serve. That is why we require all employees to be fully vaccinated against COVID-19, unless we approve an exemption through a reasonable accommodation for certified health reasons or sincerely held religious beliefs. Accommodation requests for either of these reasons should be made to Equity, Diversity, Inclusion and Affirmative Action At Blueprint Medicines, we foster a culture of equity, diversity and inclusion. A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We are also an E-Verify Employer. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires an accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to - We don't think in small steps. We think in giant leaps. We are driven by the pursuit of new ideas, new innovations, and new ways of thinking. We know that what each and every one of us matters and that our success depends on our ability to work together in a diverse community. We believe we are at our best as a company when our employees are thriving and we foster a culture that provides opportunities to grow and develop professionally, while also having fun. Job Information
          • Job ID: 62511325
          • Location:
            Cambridge, Massachusetts, United States
          • Position Title:Principal Scientist, Clinical Biomarkers, Translational MedicinePlease refer to the company's website or job descriptions to learn more about them. Associate Director, Clinical Pharmacology Cambridge, Massachusetts, United States 25 days ago Jobs You May Like Director/ Senior Director, Head of Clinical... Jounce Therapeutics Cambridge,MA,United States EdiGene Cambridge,Massachusetts,United States Director/Associate Director, Preclinical... Cambridge,Massachusetts,United States Associate Director, Clinical Pharmacology Cambridge,Massachusetts,United States Insert additional messaging here.

Keywords: American College of Clinical Pharmacology, Cambridge , Principal Scientist, Clinical Biomarkers, Translational Medicine, Education / Teaching , Cambridge, Massachusetts

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