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Principal Scientist, Medicinal Chemistry

Company: LifeMine
Location: Cambridge
Posted on: April 4, 2021

Job Description:

Principal Scientist, Medicinal Chemistry We are seeking a highly motivated, experienced medicinal chemist with a track record of invention of novel, impactful chemical matter to join our Medicinal Chemistry team. Key foci of this role are (1) design and synthesis of complex, hypothesis-driven molecules based on SAR and other relevant biological data to advance programs from natural product lead through clinical candidate nomination, (2) development and prosecution of medicinal chemistry strategy, and (3) leadership and mentorship of other scientists. Key to success will be deep knowledge and leverage of modern synthetic and medicinal chemistry strategies combined with creativity and urgency to drive our mission forward. The role also offers an opportunity to collaborate broadly through our deeply cross-functional research organization. Job Responsibilities

  • Utilize modern medicinal and synthetic chemistry strategies to design, develop, and execute synthesis of molecules to advance project goals.
  • Analyze SAR, crystallographic and other relevant biological data such as PK/PD, bioavailability, and cell permeability to design and progress new analogues from hit to lead through candidate nomination.
  • Research current literature to formulate synthetic and medicinal chemistry strategies. Evaluate and implement new reactions, techniques, and technologies to advance projects.
  • Demonstrate scientific leadership within the program team and across departments to advance our science.
  • Propose targets for and lead / manage synthesis efforts at CROs.
  • Accurately document experiments and results in laboratory notebooks in a timely fashion.
  • Maintain a safe and productive laboratory environment.
  • Prepare and present experimental results, analysis, and plans in research meetings. Job Requirements
    • PhD in organic chemistry, medicinal chemistry, or related field with 8+ years of industry experience.
    • Expert knowledge of and experience in current synthetic methods and medicinal chemistry strategies, including multiparameter optimization across potency, selectivity, and ADME properties.
    • Well-established track record of conducting innovative drug discovery research as evidenced through publications and patent applications.
    • Experience with both direct and lateral management of other medicinal and/or synthetic chemists. Experience with management of CRO resources is a plus.
    • Knowledge of and commitment to good laboratory and safety practices.
    • Excellent written, organizational and documentation skills.
    • Ability to communicate strategy and progress effectively with colleagues, managers, and senior leadership.
    • Spirit of collaborative research and sense of urgency to enable success in a team environment.
    • The successful candidate should be self-motivated, enjoy working in a fast-paced dynamic team environment, and be inspired by our mission to bring first-in-class medicines to patients who need them. LifeMine is an Equal Opportunity Employer and Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientation, gender identity, age, physical or mental disability, veteran status, genetic information, ethnicity, citizenship, or any other characteristic protected by law. If your school is not listed above, please specify below:
      If your discipline is not listed above, please specify below:
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Keywords: LifeMine, Cambridge , Principal Scientist, Medicinal Chemistry, Education / Teaching , Cambridge, Massachusetts

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